ID   ATG23_YEAS7             Reviewed;         453 AA.
AC   A7A1V1;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   03-AUG-2022, entry version 40.
DE   RecName: Full=Autophagy-related protein 23;
GN   Name=ATG23; ORFNames=SCY_3979;
OS   Saccharomyces cerevisiae (strain YJM789) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=307796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJM789;
RX   PubMed=17652520; DOI=10.1073/pnas.0701291104;
RA   Wei W., McCusker J.H., Hyman R.W., Jones T., Ning Y., Cao Z., Gu Z.,
RA   Bruno D., Miranda M., Nguyen M., Wilhelmy J., Komp C., Tamse R., Wang X.,
RA   Jia P., Luedi P., Oefner P.J., David L., Dietrich F.S., Li Y., Davis R.W.,
RA   Steinmetz L.M.;
RT   "Genome sequencing and comparative analysis of Saccharomyces cerevisiae
RT   strain YJM789.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:12825-12830(2007).
CC   -!- FUNCTION: Required for cytoplasm to vacuole transport (Cvt) vesicle
CC       formation and efficient autophagy. Plays a role in ATG protein
CC       retrieval from the pre-autophagosomal structure (PAS) and is especially
CC       required for autophagy-dependent cycling of ATG9. Also plays a role in
CC       regulation of filamentous growth (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Forms a complex with ATG9 and ATG27. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Preautophagosomal
CC       structure membrane {ECO:0000250}; Peripheral membrane protein
CC       {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein
CC       {ECO:0000250}. Note=Found in pre-autophagosomal structure and other
CC       punctate structures. Correct localization of ATG23 to the membranes is
CC       strictly dependent of ATG9. Cycling through the pre-autophagosomal
CC       structure and correct location to other punctate structures is
CC       ATG1- and ATG13-dependent (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ATG23 family. {ECO:0000305}.
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DR   EMBL; AAFW02000171; EDN59329.1; -; Genomic_DNA.
DR   AlphaFoldDB; A7A1V1; -.
DR   SMR; A7A1V1; -.
DR   PRIDE; A7A1V1; -.
DR   EnsemblFungi; EDN59329; EDN59329; SCY_3979.
DR   HOGENOM; CLU_051067_0_0_1; -.
DR   Proteomes; UP000007060; Unassembled WGS sequence.
DR   GO; GO:0034045; C:phagophore assembly site membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Autophagy; Coiled coil; Cytoplasm; Membrane; Protein transport; Transport.
FT   CHAIN           1..453
FT                   /note="Autophagy-related protein 23"
FT                   /id="PRO_0000318038"
FT   REGION          380..453
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          144..213
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        380..394
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        406..426
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   453 AA;  51537 MW;  F735C92A9A337380 CRC64;
     MELNQVLEKK EQILQYLGTL VGLHEKALSD VNSASQVTSI RKDITICLND LCRINDLLVS
     HDGLLKREIG SLLRDKQELL ELNEREQLLW KERKSWHIEQ ETDAAPADYV IDKDAIITIS
     SHHRTSLNKY IESVGAENTI LSNTDDSDAM IEEVQNAESS ADQMIRNYKL LQLSHKQAKS
     EIIRLETLLR DFKKDNKFIE EELKRQSGRI RSEMGNIDFH LSKIEESKHQ LMKRIGFESP
     LTQEKSLSEK IFNLRLSSAD EDYNERQTIN MKNFVHMKDL IELKIEDLQE QLTRNKNESS
     TVLTQRELWL DCQKKVGDLE SKLITKLRSS SNSKIPPNEM SEMINSTIQY LNNLLDSSDE
     KLTTTLISNE RDVLSKACEE LHSESTTPQD GSSALPSKPI DIHKSHKGSN ASSNLKQPST
     PSFLVASKSP PKIGISESVV NANKNDAISK KVE