PROF1_DICDI
ID PROF1_DICDI Reviewed; 126 AA.
AC P26199; Q54KQ9;
DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1992, sequence version 1.
DT 25-MAY-2022, entry version 125.
DE RecName: Full=Profilin-1;
DE AltName: Full=Profilin I;
GN Name=proA; ORFNames=DDB_G0287125;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=AX2;
RX PubMed=1725525; DOI=10.1242/jcs.100.3.481;
RA Haugwitz M., Noegel A.A., Rieger D., Lottspeich F., Schleicher M.;
RT "Dictyostelium discoideum contains two profilin isoforms that differ in
RT structure and function.";
RL J. Cell Sci. 100:481-489(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC At high concentrations, profilin prevents the polymerization of actin,
CC whereas it enhances it at low concentrations. By binding to PIP2, it
CC inhibits the formation of IP3 and DG.
CC -!- SUBUNIT: Occurs in many kinds of cells as a complex with monomeric
CC actin in a 1:1 ratio.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR EMBL; X61581; CAA43781.1; -; mRNA.
DR EMBL; AAFI02000098; EAL63837.1; -; Genomic_DNA.
DR PIR; A53255; FADO1.
DR RefSeq; XP_637371.1; XM_632279.1.
DR AlphaFoldDB; P26199; -.
DR SMR; P26199; -.
DR STRING; 44689.DDB0191178; -.
DR PaxDb; P26199; -.
DR EnsemblProtists; EAL63837; EAL63837; DDB_G0287125.
DR GeneID; 8625993; -.
DR KEGG; ddi:DDB_G0287125; -.
DR dictyBase; DDB_G0287125; proA.
DR eggNOG; KOG1755; Eukaryota.
DR HOGENOM; CLU_120772_1_1_1; -.
DR InParanoid; P26199; -.
DR OMA; WAQSSGF; -.
DR PhylomeDB; P26199; -.
DR PRO; PR:P26199; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0005938; C:cell cortex; IBA:GO_Central.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0031012; C:extracellular matrix; HDA:dictyBase.
DR GO; GO:0003779; F:actin binding; TAS:dictyBase.
DR GO; GO:0003785; F:actin monomer binding; IDA:dictyBase.
DR GO; GO:0032037; F:myosin I heavy chain binding; IPI:dictyBase.
DR GO; GO:0045010; P:actin nucleation; TAS:dictyBase.
DR GO; GO:0048870; P:cell motility; IMP:dictyBase.
DR GO; GO:0006887; P:exocytosis; IGI:dictyBase.
DR GO; GO:0000281; P:mitotic cytokinesis; IMP:dictyBase.
DR GO; GO:0030837; P:negative regulation of actin filament polymerization; IDA:dictyBase.
DR GO; GO:0050765; P:negative regulation of phagocytosis; IGI:dictyBase.
DR GO; GO:0006907; P:pinocytosis; IGI:dictyBase.
DR GO; GO:0030838; P:positive regulation of actin filament polymerization; IDA:dictyBase.
DR GO; GO:0033299; P:secretion of lysosomal enzymes; IGI:dictyBase.
DR GO; GO:0042989; P:sequestering of actin monomers; IBA:GO_Central.
DR GO; GO:0019953; P:sexual reproduction; IEP:dictyBase.
DR GO; GO:0030587; P:sorocarp development; IMP:dictyBase.
DR CDD; cd00148; PROF; 1.
DR InterPro; IPR005455; PFN.
DR InterPro; IPR036140; PFN_sf.
DR InterPro; IPR027310; Profilin_CS.
DR PANTHER; PTHR11604; PTHR11604; 1.
DR Pfam; PF00235; Profilin; 1.
DR PRINTS; PR00392; PROFILIN.
DR PRINTS; PR01640; PROFILINPLNT.
DR SMART; SM00392; PROF; 1.
DR SUPFAM; SSF55770; SSF55770; 1.
DR PROSITE; PS00414; PROFILIN; 1.
PE 2: Evidence at transcript level;
KW Actin-binding; Cytoplasm; Cytoskeleton; Reference proteome.
FT CHAIN 1..126
FT /note="Profilin-1"
FT /id="PRO_0000199594"
SQ SEQUENCE 126 AA; 13064 MW; 0A92CAD75D0CE970 CRC64;
MSWQQYVDEQ LTGAGLSQGA ILGANDGGVW AKSSGINITK PEGDGIAALF KNPAEVFAKG
ALIGGVKYMG IKGDPQSIYG KKGATGCVLV RTGQAIIVGI YDDKVQPGSA ALIVEKLGDY
LRDNGY
