ID   PROF1_HEVBR             Reviewed;         131 AA.
AC   O65812;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Profilin-1;
DE   AltName: Full=Pollen allergen Hev b 8.0101;
DE   AltName: Allergen=Hev b 8.0101;
OS   Hevea brasiliensis (Para rubber tree) (Siphonia brasiliensis).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Malpighiales; Euphorbiaceae; Crotonoideae; Micrandreae;
OC   Hevea.
OX   NCBI_TaxID=3981;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND ALLERGEN.
RC   STRAIN=cv. RRIC 133; TISSUE=Leaf;
RX   PubMed=12169172; DOI=10.1034/j.1398-9995.2002.23530.x;
RA   Nieto A., Mazon A., Boquete M., Carballada F., Asturias J.A., Martinez J.,
RA   Martinez A., Palacios R.;
RT   "Assessment of profilin as an allergen for latex-sensitized patients.";
RL   Allergy 57:776-784(2002).
CC   -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC       At high concentrations, profilin prevents the polymerization of actin,
CC       whereas it enhances it at low concentrations. By binding to PIP2, it
CC       inhibits the formation of IP3 and DG (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Occurs in many kinds of cells as a complex with monomeric
CC       actin in a 1:1 ratio.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Involved in latex
CC       allergic reactions. {ECO:0000269|PubMed:12169172}.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR   EMBL; Y15042; CAA75312.1; -; mRNA.
DR   PIR; T10769; T10769.
DR   AlphaFoldDB; O65812; -.
DR   SMR; O65812; -.
DR   Allergome; 397; Hev b 8.
DR   Allergome; 398; Hev b 8.0101.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   CDD; cd00148; PROF; 1.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR036140; PFN_sf.
DR   InterPro; IPR027310; Profilin_CS.
DR   PANTHER; PTHR11604; PTHR11604; 1.
DR   Pfam; PF00235; Profilin; 1.
DR   PRINTS; PR00392; PROFILIN.
DR   PRINTS; PR01640; PROFILINPLNT.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
DR   PROSITE; PS00414; PROFILIN; 1.
PE   1: Evidence at protein level;
KW   Actin-binding; Allergen; Cytoplasm; Cytoskeleton.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..131
FT                   /note="Profilin-1"
FT                   /id="PRO_0000199633"
SQ   SEQUENCE   131 AA;  14194 MW;  5CB0D7DA0CFCDEFA CRC64;
     MSWQTYVDER LMCEIEGNHL TAAAIIGQDG SVWAQSSNFP QFKSEEITAI MSDFDEPGTL
     APTGLHLGGT KYMVIQGEAG AVIRGKKGPG GVTVRKTNQA LIIGIYDEPM TPGQCNMIVE
     RLGDYLLEQG M