ID   PROF1_PARJU             Reviewed;         132 AA.
AC   Q9XG85;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Profilin-1;
DE   AltName: Full=Pollen allergen Par j 3.0101;
DE   AltName: Allergen=Par j 3.0101;
GN   Name=PRO1;
OS   Parietaria judaica (Pellitory-of-the-wall) (Parietaria diffusa).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Rosales; Urticaceae; Parietaria.
OX   NCBI_TaxID=33127;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pollen;
RA   Asturias J.A., Arilla M.C., Gomez-Bayon N., Martinez A., Martinez J.,
RA   Palacios R.;
RT   "Analysis of recombinant allergen Par j 3 (profilin) from Parietaria
RT   judaica.";
RL   Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC       At high concentrations, profilin prevents the polymerization of actin,
CC       whereas it enhances it at low concentrations. By binding to PIP2, it
CC       inhibits the formation of IP3 and DG (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Occurs in many kinds of cells as a complex with monomeric
CC       actin in a 1:1 ratio.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- ALLERGEN: Causes an allergic reaction in human.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR   EMBL; Y15208; CAB44256.1; -; mRNA.
DR   AlphaFoldDB; Q9XG85; -.
DR   SMR; Q9XG85; -.
DR   Allergome; 510; Par j 3.
DR   Allergome; 511; Par j 3.0101.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   CDD; cd00148; PROF; 1.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR036140; PFN_sf.
DR   InterPro; IPR027310; Profilin_CS.
DR   PANTHER; PTHR11604; PTHR11604; 1.
DR   Pfam; PF00235; Profilin; 1.
DR   PRINTS; PR00392; PROFILIN.
DR   PRINTS; PR01640; PROFILINPLNT.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
DR   PROSITE; PS00414; PROFILIN; 1.
PE   1: Evidence at protein level;
KW   Actin-binding; Allergen; Cytoplasm; Cytoskeleton.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..132
FT                   /note="Profilin-1"
FT                   /id="PRO_0000199661"
SQ   SEQUENCE   132 AA;  13920 MW;  90EE0C6E2C4F5B84 CRC64;
     MSWQAYVDDH LMCDVGDGNT PASAAIIGHD GSVWAQSANF PQLKPEEVTG IMNDFNEAGF
     LAPTGLFLGG TKYMVIQGES GAVIRGKKGS GGATLKKTGQ AIVIGIYDEP MTPGQCNLVV
     ERLGDYLLEQ GL