ID   PROF1_PHAVU             Reviewed;         131 AA.
AC   P49231;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Profilin-1;
OS   Phaseolus vulgaris (Kidney bean) (French bean).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC   NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Phaseolus.
OX   NCBI_TaxID=3885;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 47-76.
RC   STRAIN=cv. Negro Jamapa; TISSUE=Root nodule;
RX   PubMed=7784501; DOI=10.1104/pp.108.1.115;
RA   Vidali L., Perez H.E., Valdes Lopez V., Noguez R., Zamudio F., Sanchez F.;
RT   "Purification, characterization, and cDNA cloning of profilin from
RT   Phaseolus vulgaris.";
RL   Plant Physiol. 108:115-123(1995).
CC   -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC       At high concentrations, profilin prevents the polymerization of actin,
CC       whereas it enhances it at low concentrations. By binding to PIP2, it
CC       inhibits the formation of IP3 and DG.
CC   -!- SUBUNIT: Occurs in many kinds of cells as a complex with monomeric
CC       actin in a 1:1 ratio.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC   -!- TISSUE SPECIFICITY: Cytoplasmic distribution in hypocotyls. In root
CC       nodules, it is found in all cells, but is more abundant in the vascular
CC       tissue as well as the endodermis.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR   EMBL; X81982; CAA57508.1; -; mRNA.
DR   PIR; S49351; S49351.
DR   RefSeq; XP_007160275.1; XM_007160213.1.
DR   AlphaFoldDB; P49231; -.
DR   SMR; P49231; -.
DR   STRING; 3885.XP_007160275.1; -.
DR   ProMEX; P49231; -.
DR   EnsemblPlants; ESW32269; ESW32269; PHAVU_002G307600g.
DR   GeneID; 18639636; -.
DR   Gramene; ESW32269; ESW32269; PHAVU_002G307600g.
DR   KEGG; pvu:PHAVU_002G307600g; -.
DR   eggNOG; KOG1755; Eukaryota.
DR   OMA; NETMSWQ; -.
DR   OrthoDB; 1428600at2759; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   CDD; cd00148; PROF; 1.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR036140; PFN_sf.
DR   InterPro; IPR027310; Profilin_CS.
DR   PANTHER; PTHR11604; PTHR11604; 1.
DR   Pfam; PF00235; Profilin; 1.
DR   PRINTS; PR00392; PROFILIN.
DR   PRINTS; PR01640; PROFILINPLNT.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
DR   PROSITE; PS00414; PROFILIN; 1.
PE   1: Evidence at protein level;
KW   Actin-binding; Cytoplasm; Cytoskeleton; Direct protein sequencing.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..131
FT                   /note="Profilin-1"
FT                   /id="PRO_0000199666"
SQ   SEQUENCE   131 AA;  14181 MW;  7E2F1786D810EB17 CRC64;
     MSWQTYVDDH LLCEIEGNHL THAAILGQDG SVWAKSASFP QFKPEEITGI MNDFNEPGTL
     APTGLYIGGT KYMVIQGEPG SVIRGKKGPG GVTVKKTNLA LVIGIYDEPM TPGQCNMIVE
     RLGDYLIEQG L