ID   PROF1_PHYPO             Reviewed;         125 AA.
AC   P22271;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Profilin-A;
GN   Name=PROA;
OS   Physarum polycephalum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Myxogastria;
OC   Myxogastromycetidae; Physariida; Physaraceae; Physarum.
OX   NCBI_TaxID=5791;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2372376; DOI=10.1089/dna.1990.9.323;
RA   Binette F., Benard M., Laroche A., Pierron G., Lemieux G., Pallotta D.;
RT   "Cell-specific expression of a profilin gene family.";
RL   DNA Cell Biol. 9:323-334(1990).
CC   -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC       At high concentrations, profilin prevents the polymerization of actin,
CC       whereas it enhances it at low concentrations. By binding to PIP2, it
CC       inhibits the formation of IP3 and DG.
CC   -!- SUBUNIT: Occurs in many kinds of cells as a complex with monomeric
CC       actin in a 1:1 ratio.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR   EMBL; M38037; AAA63523.1; -; Genomic_DNA.
DR   PIR; A35273; A35273.
DR   AlphaFoldDB; P22271; -.
DR   SMR; P22271; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   CDD; cd00148; PROF; 1.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR036140; PFN_sf.
DR   InterPro; IPR027310; Profilin_CS.
DR   PANTHER; PTHR11604; PTHR11604; 1.
DR   Pfam; PF00235; Profilin; 1.
DR   PRINTS; PR00392; PROFILIN.
DR   PRINTS; PR01640; PROFILINPLNT.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
DR   PROSITE; PS00414; PROFILIN; 1.
PE   3: Inferred from homology;
KW   Acetylation; Actin-binding; Cytoplasm; Cytoskeleton.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..125
FT                   /note="Profilin-A"
FT                   /id="PRO_0000199600"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   125 AA;  13141 MW;  A6896B029998BE30 CRC64;
     MSWQAYVDDQ LVGTGHVIGA AIIGHDGNVW ASKNLSLKAG EGAKIVNGFK DSASVLSGGI
     FVDGQKYLTI KADDKSIYGK KGAGGVVLVK TGQSVLIGHY NETIQPGQAT TVVEKLADYL
     RENGY