ID   PROF1_RICCO             Reviewed;         131 AA.
AC   O82572;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Profilin-1;
GN   Name=PRO1;
OS   Ricinus communis (Castor bean).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Malpighiales; Euphorbiaceae; Acalyphoideae; Acalypheae;
OC   Ricinus.
OX   NCBI_TaxID=3988;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Phloem;
RA   Schobert C., Lucas W.J.;
RL   Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC       At high concentrations, profilin prevents the polymerization of actin,
CC       whereas it enhances it at low concentrations. By binding to PIP2, it
CC       inhibits the formation of IP3 and DG (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Occurs in many kinds of cells as a complex with monomeric
CC       actin in a 1:1 ratio.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR   EMBL; AF092547; AAC62482.1; -; mRNA.
DR   RefSeq; XP_002514199.1; XM_002514153.2.
DR   AlphaFoldDB; O82572; -.
DR   SMR; O82572; -.
DR   STRING; 3988.XP_002514199.1; -.
DR   Allergome; 1191; Ric c 8.
DR   GeneID; 8265128; -.
DR   KEGG; rcu:8265128; -.
DR   eggNOG; KOG1755; Eukaryota.
DR   InParanoid; O82572; -.
DR   OrthoDB; 1428600at2759; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   CDD; cd00148; PROF; 1.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR036140; PFN_sf.
DR   InterPro; IPR027310; Profilin_CS.
DR   PANTHER; PTHR11604; PTHR11604; 1.
DR   Pfam; PF00235; Profilin; 1.
DR   PRINTS; PR00392; PROFILIN.
DR   PRINTS; PR01640; PROFILINPLNT.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
DR   PROSITE; PS00414; PROFILIN; 1.
PE   2: Evidence at transcript level;
KW   Actin-binding; Cytoplasm; Cytoskeleton.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..131
FT                   /note="Profilin-1"
FT                   /id="PRO_0000199671"
SQ   SEQUENCE   131 AA;  14208 MW;  8517DA524851DE09 CRC64;
     MSWQTYVDDH LMCEIEGNHL TSAAIIGQDG SVWAQSSTFP QFKPEEITAI MNDFNEPGSL
     APTGLYLSGT KYMVIQGEPG AVIRGKKGPG GVTVKKTNQA LIIGIYDEPM TPGQCNMIVE
     RLGDYLIDQG L