ID   PROF1_SOLLC             Reviewed;         133 AA.
AC   Q41344;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Profilin-1;
GN   Name=PRO1;
OS   Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC   Solanum subgen. Lycopersicon.
OX   NCBI_TaxID=4081;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Moneymaker; TISSUE=Pollen;
RX   PubMed=9526502; DOI=10.1023/a:1005971327353;
RA   Yu L.X., Nasrallah J., Valenta R., Parthasarathy M.V.;
RT   "Molecular cloning and mRNA localization of tomato pollen profilin.";
RL   Plant Mol. Biol. 36:699-707(1998).
CC   -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC       At high concentrations, profilin prevents the polymerization of actin,
CC       whereas it enhances it at low concentrations. By binding to PIP2, it
CC       inhibits the formation of IP3 and DG (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Occurs in many kinds of cells as a complex with monomeric
CC       actin in a 1:1 ratio.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Ubiquitous.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U50195; AAB03271.1; -; mRNA.
DR   PIR; T07856; T07856.
DR   RefSeq; NP_001233869.1; NM_001246940.1.
DR   AlphaFoldDB; Q41344; -.
DR   SMR; Q41344; -.
DR   STRING; 4081.Solyc12g044630.1.1; -.
DR   Allergome; 703; Sola l 1.
DR   PaxDb; Q41344; -.
DR   PRIDE; Q41344; -.
DR   EnsemblPlants; Solyc12g044630.2.1; Solyc12g044630.2.1; Solyc12g044630.2.
DR   GeneID; 544018; -.
DR   Gramene; Solyc12g044630.2.1; Solyc12g044630.2.1; Solyc12g044630.2.
DR   KEGG; sly:544018; -.
DR   eggNOG; KOG1755; Eukaryota.
DR   HOGENOM; CLU_120772_0_1_1; -.
DR   InParanoid; Q41344; -.
DR   OMA; TIQPAEM; -.
DR   OrthoDB; 1428600at2759; -.
DR   PhylomeDB; Q41344; -.
DR   Proteomes; UP000004994; Chromosome 12.
DR   GO; GO:0005938; C:cell cortex; IBA:GO_Central.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003785; F:actin monomer binding; IBA:GO_Central.
DR   GO; GO:0042989; P:sequestering of actin monomers; IBA:GO_Central.
DR   CDD; cd00148; PROF; 1.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR036140; PFN_sf.
DR   InterPro; IPR027310; Profilin_CS.
DR   PANTHER; PTHR11604; PTHR11604; 1.
DR   Pfam; PF00235; Profilin; 1.
DR   PRINTS; PR00392; PROFILIN.
DR   PRINTS; PR01640; PROFILINPLNT.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
DR   PROSITE; PS00414; PROFILIN; 1.
PE   2: Evidence at transcript level;
KW   Actin-binding; Cytoplasm; Cytoskeleton; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..133
FT                   /note="Profilin-1"
FT                   /id="PRO_0000199644"
SQ   SEQUENCE   133 AA;  14434 MW;  5F15CDEF26EE3B84 CRC64;
     MSWQTYVDDH LMCDIEGTGH HLSSAAILGF DGSVWAQSPN FPKFKAEEIT NIMKDFDEPG
     HLAPTGLFLA GTKYMVIQGE PGAVIRGKKG PGGITIKKTA QALIFGVYEE PVTPGQCNMV
     VEKIGDYLVD QGY