ID   PROF1_STRPU             Reviewed;         142 AA.
AC   P32006;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Profilin;
DE   AltName: Full=SpCoel1;
OS   Strongylocentrotus purpuratus (Purple sea urchin).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Camarodonta; Echinidea; Strongylocentrotidae;
OC   Strongylocentrotus.
OX   NCBI_TaxID=7668;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1498361; DOI=10.1091/mbc.3.4.403;
RA   Smith L.C., Britten R.J., Davidson E.H.;
RT   "SpCoel1: a sea urchin profilin gene expressed specifically in coelomocytes
RT   in response to injury.";
RL   Mol. Biol. Cell 3:403-414(1992).
CC   -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC       At high concentrations, profilin prevents the polymerization of actin,
CC       whereas it enhances it at low concentrations. By binding to PIP2, it
CC       inhibits the formation of IP3 and DG.
CC   -!- SUBUNIT: Occurs in many kinds of cells as a complex with monomeric
CC       actin in a 1:1 ratio.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC   -!- TISSUE SPECIFICITY: Expressed specifically in coelomocytes in response
CC       to injury.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR   EMBL; S42185; AAB22843.1; -; mRNA.
DR   PIR; A44777; A44777.
DR   RefSeq; NP_999760.1; NM_214595.1.
DR   AlphaFoldDB; P32006; -.
DR   SMR; P32006; -.
DR   STRING; 7668.SPU_020197-tr; -.
DR   PRIDE; P32006; -.
DR   EnsemblMetazoa; NM_214595; NP_999760; GeneID_373409.
DR   GeneID; 373409; -.
DR   KEGG; spu:373409; -.
DR   CTD; 373409; -.
DR   eggNOG; KOG1755; Eukaryota.
DR   HOGENOM; CLU_2471924_0_0_1; -.
DR   OMA; VKYQFLR; -.
DR   OrthoDB; 1428600at2759; -.
DR   PhylomeDB; P32006; -.
DR   Proteomes; UP000007110; Unassembled WGS sequence.
DR   GO; GO:0005938; C:cell cortex; IBA:GO_Central.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003785; F:actin monomer binding; IBA:GO_Central.
DR   GO; GO:0042989; P:sequestering of actin monomers; IBA:GO_Central.
DR   CDD; cd00148; PROF; 1.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR036140; PFN_sf.
DR   InterPro; IPR027310; Profilin_CS.
DR   PANTHER; PTHR11604; PTHR11604; 1.
DR   Pfam; PF00235; Profilin; 1.
DR   PRINTS; PR00392; PROFILIN.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
DR   PROSITE; PS00414; PROFILIN; 1.
PE   2: Evidence at transcript level;
KW   Actin-binding; Cytoplasm; Cytoskeleton; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..142
FT                   /note="Profilin"
FT                   /id="PRO_0000199602"
SQ   SEQUENCE   142 AA;  15282 MW;  D38D8B60B22C78F0 CRC64;
     MSWDSYVDNL IAQSKDASGT THCDKACIIG KDGSAWTTMP TSDTSNNLKL TPEEMANIAK
     CFKSKDFAAF MSSGIYVNGT KYQFLREEDS KLVLGKKKGE GSLTLQSSKT AIVIGHCPEG
     GQQGNLNKAV GVIAEYLESL SM