ID   PROF1_TOBAC             Reviewed;         134 AA.
AC   P41372;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Profilin-1;
GN   Name=PRO1;
OS   Nicotiana tabacum (Common tobacco).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC   Nicotiana.
OX   NCBI_TaxID=4097;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Petit Havana; TISSUE=Pollen;
RX   PubMed=7865783; DOI=10.1007/bf00019185;
RA   Mittermann I., Swoboda I., Pierson E., Eller N., Kraft D., Valenta R.,
RA   Heberle-Bors E.;
RT   "Molecular cloning and characterization of profilin from tobacco (Nicotiana
RT   tabacum): increased profilin expression during pollen maturation.";
RL   Plant Mol. Biol. 27:137-146(1995).
CC   -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC       At high concentrations, profilin prevents the polymerization of actin,
CC       whereas it enhances it at low concentrations. By binding to PIP2, it
CC       inhibits the formation of IP3 and DG.
CC   -!- SUBUNIT: Occurs in many kinds of cells as a complex with monomeric
CC       actin in a 1:1 ratio.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR   EMBL; X82120; CAA57632.1; -; mRNA.
DR   PIR; S51835; S51835.
DR   AlphaFoldDB; P41372; -.
DR   SMR; P41372; -.
DR   Allergome; 1407; Nic t 8.
DR   Proteomes; UP000084051; Unplaced.
DR   GO; GO:0005938; C:cell cortex; IBA:GO_Central.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003785; F:actin monomer binding; IBA:GO_Central.
DR   GO; GO:0042989; P:sequestering of actin monomers; IBA:GO_Central.
DR   CDD; cd00148; PROF; 1.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR036140; PFN_sf.
DR   InterPro; IPR027310; Profilin_CS.
DR   PANTHER; PTHR11604; PTHR11604; 1.
DR   Pfam; PF00235; Profilin; 1.
DR   PRINTS; PR00392; PROFILIN.
DR   PRINTS; PR01640; PROFILINPLNT.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
DR   PROSITE; PS00414; PROFILIN; 1.
PE   2: Evidence at transcript level;
KW   Actin-binding; Cytoplasm; Cytoskeleton; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..134
FT                   /note="Profilin-1"
FT                   /id="PRO_0000199674"
SQ   SEQUENCE   134 AA;  14621 MW;  547D25859796E6DE CRC64;
     MSWQTYVDDH LMADIEGQQG HHLAAAAILG HDGSVWAQSS TFPKFKPEEI TNIMKDFDEP
     GHLAPTGLFL GGAKYMVIQG EPGAVIRGKK GSGGITIKKT NQALIFGIYE EPVTPGQCNM
     VVEKIRDYLV DQGY