ID   PROF1_WHEAT             Reviewed;         131 AA.
AC   P49232;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   19-FEB-2014, sequence version 2.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Profilin-1;
GN   Name=PRO1;
OS   Triticum aestivum (Wheat).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX   NCBI_TaxID=4565;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. TAM 107;
RX   PubMed=7920020; DOI=10.1159/000236824;
RA   Rihs H.-P., Rozynek P., May-Taube K., Welticke B., Baur X.;
RT   "Polymerase chain reaction based cDNA cloning of wheat profilin: a
RT   potential plant allergen.";
RL   Int. Arch. Allergy Immunol. 105:190-194(1994).
CC   -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC       At high concentrations, profilin prevents the polymerization of actin,
CC       whereas it enhances it at low concentrations. By binding to PIP2, it
CC       inhibits the formation of IP3 and DG.
CC   -!- SUBUNIT: Occurs in many kinds of cells as a complex with monomeric
CC       actin in a 1:1 ratio.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR   EMBL; X89825; CAA61943.2; -; mRNA.
DR   PIR; T06551; T06551.
DR   AlphaFoldDB; P49232; -.
DR   SMR; P49232; -.
DR   STRING; 4565.Traes_7AS_DA1089F6B.2; -.
DR   Allergome; 3498; Tri a 12.0101.
DR   Allergome; 767; Tri a 12.
DR   Proteomes; UP000019116; Unplaced.
DR   ExpressionAtlas; P49232; baseline and differential.
DR   GO; GO:0005938; C:cell cortex; IBA:GO_Central.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003785; F:actin monomer binding; IBA:GO_Central.
DR   GO; GO:0042989; P:sequestering of actin monomers; IBA:GO_Central.
DR   CDD; cd00148; PROF; 1.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR036140; PFN_sf.
DR   InterPro; IPR027310; Profilin_CS.
DR   PANTHER; PTHR11604; PTHR11604; 1.
DR   Pfam; PF00235; Profilin; 1.
DR   PRINTS; PR00392; PROFILIN.
DR   PRINTS; PR01640; PROFILINPLNT.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
DR   PROSITE; PS00414; PROFILIN; 1.
PE   2: Evidence at transcript level;
KW   Actin-binding; Cytoplasm; Cytoskeleton; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..131
FT                   /note="Profilin-1"
FT                   /id="PRO_0000199677"
SQ   SEQUENCE   131 AA;  14224 MW;  3D0B5D2CD1E015D1 CRC64;
     MSWQTYVDDH LCCEIDGQHL TSAAILGHDG SVWTESPNFP KFKPEEIAGI VKDFEEPGHL
     APTGLFLGGT KYMVIQGEPG VVIRGKKGTG GITIKKTGMA LILGIYDEPM TPGQCNLVVE
     RLGDYLIDQG Y