ID   PROF2_ARTVU             Reviewed;         133 AA.
AC   Q8H2C8;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Profilin-2;
DE   AltName: Full=Pollen allergen Art v 4.02;
DE   AltName: Allergen=Art v 4.02;
OS   Artemisia vulgaris (Mugwort).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; campanulids; Asterales; Asteraceae; Asteroideae; Anthemideae;
OC   Artemisiinae; Artemisia.
OX   NCBI_TaxID=4220;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pollen;
RX   PubMed=12530543; DOI=10.1515/bc.2002.199;
RA   Wopfner N., Willeroidee M., Hebenstreit D., van Ree R., Aalbers M.,
RA   Briza P., Thalhamer J., Ebner C., Richter K., Ferreira F.;
RT   "Molecular and immunological characterization of profilin from mugwort
RT   pollen.";
RL   Biol. Chem. 383:1779-1789(2002).
CC   -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC       At high concentrations, profilin prevents the polymerization of actin,
CC       whereas it enhances it at low concentrations. By binding to PIP2, it
CC       inhibits the formation of IP3 and DG (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Occurs in many kinds of cells as a complex with monomeric
CC       actin in a 1:1 ratio.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- ALLERGEN: Causes an allergic reaction in human.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR   EMBL; AJ421031; CAD12862.1; -; mRNA.
DR   AlphaFoldDB; Q8H2C8; -.
DR   SMR; Q8H2C8; -.
DR   Allergome; 1653; Art v 4.0201.
DR   Allergome; 60; Art v 4.
DR   PRIDE; Q8H2C8; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   CDD; cd00148; PROF; 1.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR036140; PFN_sf.
DR   InterPro; IPR027310; Profilin_CS.
DR   PANTHER; PTHR11604; PTHR11604; 1.
DR   Pfam; PF00235; Profilin; 1.
DR   PRINTS; PR00392; PROFILIN.
DR   PRINTS; PR01640; PROFILINPLNT.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
DR   PROSITE; PS00414; PROFILIN; 1.
PE   1: Evidence at protein level;
KW   Actin-binding; Allergen; Cytoplasm; Cytoskeleton.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..133
FT                   /note="Profilin-2"
FT                   /id="PRO_0000199621"
SQ   SEQUENCE   133 AA;  14315 MW;  051DEDAF98E624F2 CRC64;
     MSWQTYVDDH LMCDIEGTGQ HLTAAAILGL DGTVWAKSDK FPEFKPEEMK GIINEFNEVG
     TLAPTGLFLG GAKYMVLQGE AGAVIRGKKG AGGICIKKTG QAMVMGIYDE PVAPGQCNMI
     VERLGDYLVD QNM