ID   PROF2_DICDI             Reviewed;         124 AA.
AC   P26200; Q54M07;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1992, sequence version 1.
DT   25-MAY-2022, entry version 130.
DE   RecName: Full=Profilin-2;
DE   AltName: Full=Profilin II;
GN   Name=proB; ORFNames=DDB_G0286187;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=AX2;
RX   PubMed=1725525; DOI=10.1242/jcs.100.3.481;
RA   Haugwitz M., Noegel A.A., Rieger D., Lottspeich F., Schleicher M.;
RT   "Dictyostelium discoideum contains two profilin isoforms that differ in
RT   structure and function.";
RL   J. Cell Sci. 100:481-489(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [3]
RP   INTERACTION WITH FORH.
RC   STRAIN=AX2;
RX   PubMed=15908944; DOI=10.1038/ncb1266;
RA   Schirenbeck A., Bretschneider T., Arasada R., Schleicher M., Faix J.;
RT   "The Diaphanous-related formin dDia2 is required for the formation and
RT   maintenance of filopodia.";
RL   Nat. Cell Biol. 7:619-625(2005).
CC   -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC       At high concentrations, profilin prevents the polymerization of actin,
CC       whereas it enhances it at low concentrations. By binding to PIP2, it
CC       inhibits the formation of IP3 and DG.
CC   -!- SUBUNIT: Occurs in many kinds of cells as a complex with monomeric
CC       actin in a 1:1 ratio. Interacts with forH.
CC       {ECO:0000269|PubMed:15908944}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR   EMBL; X61580; CAA43780.1; -; mRNA.
DR   EMBL; AAFI02000085; EAL64269.1; -; Genomic_DNA.
DR   PIR; B53255; FADO2.
DR   RefSeq; XP_637824.1; XM_632732.1.
DR   AlphaFoldDB; P26200; -.
DR   SMR; P26200; -.
DR   IntAct; P26200; 1.
DR   STRING; 44689.DDB0191249; -.
DR   PaxDb; P26200; -.
DR   EnsemblProtists; EAL64269; EAL64269; DDB_G0286187.
DR   GeneID; 8625538; -.
DR   KEGG; ddi:DDB_G0286187; -.
DR   dictyBase; DDB_G0286187; proB.
DR   eggNOG; KOG1755; Eukaryota.
DR   HOGENOM; CLU_120772_1_1_1; -.
DR   InParanoid; P26200; -.
DR   OMA; TIQPAEM; -.
DR   PhylomeDB; P26200; -.
DR   PRO; PR:P26200; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0015629; C:actin cytoskeleton; TAS:dictyBase.
DR   GO; GO:0005938; C:cell cortex; IBA:GO_Central.
DR   GO; GO:0031012; C:extracellular matrix; HDA:dictyBase.
DR   GO; GO:0003779; F:actin binding; TAS:dictyBase.
DR   GO; GO:0003785; F:actin monomer binding; IDA:dictyBase.
DR   GO; GO:0032037; F:myosin I heavy chain binding; IPI:dictyBase.
DR   GO; GO:0045010; P:actin nucleation; TAS:dictyBase.
DR   GO; GO:0048870; P:cell motility; IMP:dictyBase.
DR   GO; GO:0006887; P:exocytosis; IGI:dictyBase.
DR   GO; GO:0006972; P:hyperosmotic response; IEP:dictyBase.
DR   GO; GO:0000281; P:mitotic cytokinesis; IMP:dictyBase.
DR   GO; GO:0030837; P:negative regulation of actin filament polymerization; IDA:dictyBase.
DR   GO; GO:0050765; P:negative regulation of phagocytosis; IGI:dictyBase.
DR   GO; GO:0006907; P:pinocytosis; IGI:dictyBase.
DR   GO; GO:0030838; P:positive regulation of actin filament polymerization; IDA:dictyBase.
DR   GO; GO:0033299; P:secretion of lysosomal enzymes; IGI:dictyBase.
DR   GO; GO:0042989; P:sequestering of actin monomers; IBA:GO_Central.
DR   GO; GO:0030587; P:sorocarp development; IMP:dictyBase.
DR   CDD; cd00148; PROF; 1.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR036140; PFN_sf.
DR   InterPro; IPR027310; Profilin_CS.
DR   PANTHER; PTHR11604; PTHR11604; 1.
DR   Pfam; PF00235; Profilin; 1.
DR   PRINTS; PR00392; PROFILIN.
DR   PRINTS; PR01640; PROFILINPLNT.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
DR   PROSITE; PS00414; PROFILIN; 1.
PE   1: Evidence at protein level;
KW   Actin-binding; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..124
FT                   /note="Profilin-2"
FT                   /id="PRO_0000199595"
SQ   SEQUENCE   124 AA;  12730 MW;  04F5617BF0DB5A8F CRC64;
     MTWQAYVDNN LLGAGFASAA LLGAADGSVW AHSAGFNVAE GKAITALFQK DGAAFATGIH
     VAGKKYMAIK SDTRSAYGKL GAGGVVCVKT LTCIIVAVYD DKLQPGAAAN IAEKLADYLI
     DNNC