ID   PROF2_MALDO             Reviewed;         131 AA.
AC   Q9XF41;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Profilin-2;
DE   AltName: Full=GD4-2;
DE   AltName: Full=Pollen allergen Mal d 4.0201;
DE   AltName: Allergen=Mal d 4.0201;
OS   Malus domestica (Apple) (Pyrus malus).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Maleae; Malus.
OX   NCBI_TaxID=3750;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Golden Delicious;
RA   Scheurer S., Wangorsch A., Haustein D., Vieths S.;
RT   "Characterization of profilin from apple as the allergen Mal d 4.";
RL   Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC       At high concentrations, profilin prevents the polymerization of actin,
CC       whereas it enhances it at low concentrations. By binding to PIP2, it
CC       inhibits the formation of IP3 and DG (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Occurs in many kinds of cells as a complex with monomeric
CC       actin in a 1:1 ratio.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- ALLERGEN: Causes an allergic reaction in human.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR   EMBL; AF129427; AAD29413.1; -; mRNA.
DR   AlphaFoldDB; Q9XF41; -.
DR   SMR; Q9XF41; -.
DR   STRING; 3750.XP_008337609.1; -.
DR   Allergome; 2416; Mal d 4.0201.
DR   Allergome; 796; Mal d 4.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   CDD; cd00148; PROF; 1.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR036140; PFN_sf.
DR   InterPro; IPR027310; Profilin_CS.
DR   PANTHER; PTHR11604; PTHR11604; 1.
DR   Pfam; PF00235; Profilin; 1.
DR   PRINTS; PR00392; PROFILIN.
DR   PRINTS; PR01640; PROFILINPLNT.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
DR   PROSITE; PS00414; PROFILIN; 1.
PE   1: Evidence at protein level;
KW   Actin-binding; Allergen; Cytoplasm; Cytoskeleton.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..131
FT                   /note="Profilin-2"
FT                   /id="PRO_0000199652"
SQ   SEQUENCE   131 AA;  14052 MW;  AEDEC3ECAD8B1A56 CRC64;
     MSWQAYVDDH LMCEIEGNHL SAAAIIGHNG SVWAQSATFP QLKPEEVTGI MNDFNEPGSL
     APTGLYLGGT KYMVIQGEPG VVIRGKKGPG GVTVKKSTMA LLIGIYDEPM TPGQCNMVVE
     RLGDYLIEQG L