ID   PROF2_PARJU             Reviewed;         131 AA.
AC   Q9T0M8;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Profilin-2;
DE   AltName: Full=Pollen allergen Par j 3.0102;
DE   AltName: Allergen=Par j 3.0102;
GN   Name=PRO2;
OS   Parietaria judaica (Pellitory-of-the-wall) (Parietaria diffusa).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Rosales; Urticaceae; Parietaria.
OX   NCBI_TaxID=33127;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pollen;
RA   Asturias J.A., Arilla M.C., Gomez-Bayon N., Martinez A., Martinez J.,
RA   Palacios R.;
RT   "Analysis of recombinant allergen Par j 3 (profilin) from Parietaria
RT   judaica.";
RL   Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC       At high concentrations, profilin prevents the polymerization of actin,
CC       whereas it enhances it at low concentrations. By binding to PIP2, it
CC       inhibits the formation of IP3 and DG (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Occurs in many kinds of cells as a complex with monomeric
CC       actin in a 1:1 ratio.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- ALLERGEN: Causes an allergic reaction in human.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR   EMBL; Y15209; CAB44257.1; -; mRNA.
DR   AlphaFoldDB; Q9T0M8; -.
DR   SMR; Q9T0M8; -.
DR   Allergome; 510; Par j 3.
DR   Allergome; 512; Par j 3.0102.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   CDD; cd00148; PROF; 1.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR036140; PFN_sf.
DR   InterPro; IPR027310; Profilin_CS.
DR   PANTHER; PTHR11604; PTHR11604; 1.
DR   Pfam; PF00235; Profilin; 1.
DR   PRINTS; PR00392; PROFILIN.
DR   PRINTS; PR01640; PROFILINPLNT.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
DR   PROSITE; PS00414; PROFILIN; 1.
PE   1: Evidence at protein level;
KW   Actin-binding; Allergen; Cytoplasm; Cytoskeleton.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..131
FT                   /note="Profilin-2"
FT                   /id="PRO_0000199662"
SQ   SEQUENCE   131 AA;  13784 MW;  8A4FCC0BAC1565AB CRC64;
     MSWQAYVDDH LMCDVGDGNT LASAAIIGHD GSVWAQSANF PQLKPEEVTG IMNDFNEGGF
     LAPTGLFLGG TKYMVIQGES GAVIGKKGSG GATLKKTGQA IVIGIYDEPM TPGQCNLVVE
     RLGDYLLEQG M