ID   PROF3_AMBAR             Reviewed;         133 AA.
AC   Q64LH0;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 47.
DE   RecName: Full=Profilin-3;
DE   AltName: Full=Pollen allergen D03;
DE   AltName: Allergen=Amb a 8;
GN   ORFNames=D03;
OS   Ambrosia artemisiifolia (Common ragweed).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; campanulids; Asterales; Asteraceae; Asteroideae;
OC   Heliantheae alliance; Heliantheae; Ambrosia.
OX   NCBI_TaxID=4212;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pollen;
RA   Tao A.L., He S.H., Zhang L., Chen Z., Li D.;
RT   "Cloning and sequence analysis of grass pollen panallergens in Humulus
RT   scandens (Lour.) Merr and short ragweed (Ambrosia artemisiifolia L.).";
RL   Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC       At high concentrations, profilin prevents the polymerization of actin,
CC       whereas it enhances it at low concentrations. By binding to PIP2, it
CC       inhibits the formation of IP3 and DG (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Occurs in many kinds of cells as a complex with monomeric
CC       actin in a 1:1 ratio.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- ALLERGEN: Causes an allergic reaction in human.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR   EMBL; AY268427; AAP15203.1; -; mRNA.
DR   AlphaFoldDB; Q64LH0; -.
DR   SMR; Q64LH0; -.
DR   Allergome; 751; Amb a 8.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   CDD; cd00148; PROF; 1.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR036140; PFN_sf.
DR   InterPro; IPR027310; Profilin_CS.
DR   PANTHER; PTHR11604; PTHR11604; 1.
DR   Pfam; PF00235; Profilin; 1.
DR   PRINTS; PR00392; PROFILIN.
DR   PRINTS; PR01640; PROFILINPLNT.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
DR   PROSITE; PS00414; PROFILIN; 1.
PE   1: Evidence at protein level;
KW   Actin-binding; Allergen; Cytoplasm; Cytoskeleton.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..133
FT                   /note="Profilin-3"
FT                   /id="PRO_0000199611"
SQ   SEQUENCE   133 AA;  14277 MW;  2DD005FB8EFF24AB CRC64;
     MSWQAYVDEH LMCDIEGTGH HLTSAAILGH DGTVWAQSSN FPQFKPEEMK GIITEFDQAG
     TLAPTGMFIA GAKYMVLQGE QGAVIRGKKG AGGICIKKTG QALVMGIYDE PVAPGQCNMV
     VERLGDYLID QGM