ID   PROF3_BOVIN             Reviewed;         137 AA.
AC   Q32PB1;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Profilin-3;
GN   Name=PFN3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC       Binds to poly-L-proline, phosphatidylinositol 3-phosphate (PtdIns(3)P),
CC       phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and
CC       phosphatidylinositol 4-phosphate (PtdIns(4)P). Slightly reduces actin
CC       polymerization. May be involved in spermatogenesis. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with ACTRT3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR   EMBL; BC108188; AAI08189.1; -; mRNA.
DR   RefSeq; NP_001071413.1; NM_001077945.2.
DR   AlphaFoldDB; Q32PB1; -.
DR   SMR; Q32PB1; -.
DR   STRING; 9913.ENSBTAP00000054439; -.
DR   PaxDb; Q32PB1; -.
DR   Ensembl; ENSBTAT00000027123; ENSBTAP00000054439; ENSBTAG00000020353.
DR   GeneID; 521379; -.
DR   KEGG; bta:521379; -.
DR   CTD; 345456; -.
DR   VEuPathDB; HostDB:ENSBTAG00000020353; -.
DR   VGNC; VGNC:32777; PFN3.
DR   eggNOG; ENOG502S2A3; Eukaryota.
DR   GeneTree; ENSGT00940000153664; -.
DR   HOGENOM; CLU_123405_1_0_1; -.
DR   InParanoid; Q32PB1; -.
DR   OMA; VCVGHTP; -.
DR   OrthoDB; 1428600at2759; -.
DR   TreeFam; TF331744; -.
DR   Proteomes; UP000009136; Chromosome 7.
DR   Bgee; ENSBTAG00000020353; Expressed in semen and 40 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IBA:GO_Central.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR   GO; GO:0032233; P:positive regulation of actin filament bundle assembly; IBA:GO_Central.
DR   GO; GO:0030833; P:regulation of actin filament polymerization; IBA:GO_Central.
DR   CDD; cd00148; PROF; 1.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR029893; PFN3.
DR   InterPro; IPR036140; PFN_sf.
DR   InterPro; IPR005454; Profilin1/2/3_vertebrate.
DR   PANTHER; PTHR13936:SF2; PTHR13936:SF2; 1.
DR   Pfam; PF00235; Profilin; 1.
DR   PRINTS; PR01639; PROFILINMAML.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
PE   2: Evidence at transcript level;
KW   Actin-binding; Cytoplasm; Cytoskeleton; Lipid-binding; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..137
FT                   /note="Profilin-3"
FT                   /id="PRO_0000243934"
SQ   SEQUENCE   137 AA;  14629 MW;  940DA526DD005FCD CRC64;
     MGDWKGYISA VLRDQRIDDV AIVGHSDNRC VWASRPGGLL AAISPQEVGV LTGPDRSTFL
     QAGLCVAGRR CCVIRDHLLA EGDGVLDART KGLDGRAICV GHTPRALLVL MGRRGVHGGI
     LNKTMHELIH GLRSQGT