PROF3_HUMAN
ID PROF3_HUMAN Reviewed; 137 AA.
AC P60673; A2RUL3;
DT 29-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 29-MAR-2004, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Profilin-3;
DE AltName: Full=Profilin III;
GN Name=PFN3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11867228; DOI=10.1016/s0378-1119(01)00855-1;
RA Braun A., Aszodi A., Hellebrand H., Berna A., Fassler R., Brandau O.;
RT "Genomic organization of profilin-III and evidence for a transcript
RT expressed exclusively in testis.";
RL Gene 283:219-225(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP FUNCTION.
RX PubMed=19419568; DOI=10.1186/1471-2121-10-34;
RA Behnen M., Murk K., Kursula P., Cappallo-Obermann H., Rothkegel M.,
RA Kierszenbaum A.L., Kirchhoff C.;
RT "Testis-expressed profilins 3 and 4 show distinct functional
RT characteristics and localize in the acroplaxome-manchette complex in
RT spermatids.";
RL BMC Cell Biol. 10:34-34(2009).
CC -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC Slightly reduces actin polymerization. Binds to poly-L-proline,
CC phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol
CC 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 4-phosphate
CC (PtdIns(4)P). May be involved in spermatogenesis.
CC {ECO:0000269|PubMed:19419568}.
CC -!- SUBUNIT: Interacts with ACTRT3. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus
CC {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Testis specific.
CC -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR EMBL; AC090063; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471195; EAW85006.1; -; Genomic_DNA.
DR EMBL; BC132952; AAI32953.1; -; mRNA.
DR EMBL; BC132954; AAI32955.1; -; mRNA.
DR CCDS; CCDS34301.1; -.
DR RefSeq; NP_001025057.1; NM_001029886.2.
DR AlphaFoldDB; P60673; -.
DR SMR; P60673; -.
DR BioGRID; 131350; 13.
DR STRING; 9606.ENSP00000351379; -.
DR iPTMnet; P60673; -.
DR PhosphoSitePlus; P60673; -.
DR BioMuta; PFN3; -.
DR DMDM; 48474309; -.
DR jPOST; P60673; -.
DR MassIVE; P60673; -.
DR MaxQB; P60673; -.
DR PaxDb; P60673; -.
DR PeptideAtlas; P60673; -.
DR PRIDE; P60673; -.
DR ProteomicsDB; 57223; -.
DR Antibodypedia; 48836; 20 antibodies from 3 providers.
DR DNASU; 345456; -.
DR Ensembl; ENST00000358571.3; ENSP00000351379.2; ENSG00000196570.3.
DR GeneID; 345456; -.
DR KEGG; hsa:345456; -.
DR MANE-Select; ENST00000358571.3; ENSP00000351379.2; NM_001029886.3; NP_001025057.1.
DR UCSC; uc003mgl.2; human.
DR CTD; 345456; -.
DR DisGeNET; 345456; -.
DR GeneCards; PFN3; -.
DR HGNC; HGNC:18627; PFN3.
DR HPA; ENSG00000196570; Tissue enriched (testis).
DR MIM; 612812; gene.
DR neXtProt; NX_P60673; -.
DR OpenTargets; ENSG00000196570; -.
DR PharmGKB; PA142671182; -.
DR VEuPathDB; HostDB:ENSG00000196570; -.
DR eggNOG; ENOG502S2A3; Eukaryota.
DR GeneTree; ENSGT00940000153664; -.
DR HOGENOM; CLU_123405_1_0_1; -.
DR InParanoid; P60673; -.
DR OMA; VCVGHTP; -.
DR OrthoDB; 1428600at2759; -.
DR PhylomeDB; P60673; -.
DR TreeFam; TF331744; -.
DR PathwayCommons; P60673; -.
DR BioGRID-ORCS; 345456; 9 hits in 1070 CRISPR screens.
DR ChiTaRS; PFN3; human.
DR GenomeRNAi; 345456; -.
DR Pharos; P60673; Tdark.
DR PRO; PR:P60673; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; P60673; protein.
DR Bgee; ENSG00000196570; Expressed in right testis and 16 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IBA:GO_Central.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR GO; GO:0032233; P:positive regulation of actin filament bundle assembly; IBA:GO_Central.
DR GO; GO:0030833; P:regulation of actin filament polymerization; IBA:GO_Central.
DR CDD; cd00148; PROF; 1.
DR InterPro; IPR005455; PFN.
DR InterPro; IPR029893; PFN3.
DR InterPro; IPR036140; PFN_sf.
DR InterPro; IPR005454; Profilin1/2/3_vertebrate.
DR PANTHER; PTHR13936:SF2; PTHR13936:SF2; 1.
DR Pfam; PF00235; Profilin; 1.
DR PRINTS; PR01639; PROFILINMAML.
DR SMART; SM00392; PROF; 1.
DR SUPFAM; SSF55770; SSF55770; 1.
PE 2: Evidence at transcript level;
KW Actin-binding; Cytoplasm; Cytoskeleton; Lipid-binding; Nucleus;
KW Reference proteome.
FT CHAIN 1..137
FT /note="Profilin-3"
FT /id="PRO_0000199579"
SQ SEQUENCE 137 AA; 14596 MW; 9D1456E89AE6F1C8 CRC64;
MGDWKVYISA VLRDQRIDDV AIVGHADNSC VWASRPGGLL AAISPQEVGV LTGPDRHTFL
QAGLSVGGRR CCVIRDHLLA EGDGVLDART KGLDARAVCV GRAPRALLVL MGRRGVHGGI
LNKTVHELIR GLRMQGA
