ID   PROF3_LOKSG             Reviewed;         123 AA.
AC   A0A0F8VPX6;
DT   12-AUG-2020, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2015, sequence version 1.
DT   25-MAY-2022, entry version 17.
DE   RecName: Full=Loki profilin-3 {ECO:0000303|PubMed:30283132};
GN   ORFNames=Lokiarch_01510;
OS   Lokiarchaeum sp. (strain GC14_75).
OC   Archaea; Asgard group; Candidatus Lokiarchaeota; Lokiarchaeum;
OC   unclassified Lokiarchaeum.
OX   NCBI_TaxID=1538547;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GC14_75;
RX   PubMed=25945739; DOI=10.1038/nature14447;
RA   Spang A., Saw J.H., Jorgensen S.L., Zaremba-Niedzwiedzka K., Martijn J.,
RA   Lind A.E., van Eijk R., Schleper C., Guy L., Ettema T.J.;
RT   "Complex archaea that bridge the gap between prokaryotes and eukaryotes.";
RL   Nature 521:173-179(2015).
RN   [2]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=30283132; DOI=10.1038/s41586-018-0548-6;
RA   Akil C., Robinson R.C.;
RT   "Genomes of Asgard archaea encode profilins that regulate actin.";
RL   Nature 562:439-443(2018).
CC   -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC       At high concentrations inhibits spontaneous rabbit actin nucleation.
CC       This strongly suggests this archaea has a profilin-regulated actin
CC       system, and actin-type genes can be identified in this organism.
CC       {ECO:0000269|PubMed:30283132}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000305|PubMed:30283132}.
CC   -!- MISCELLANEOUS: It is not clear if Loki profilins 1, 2 and 3 are from
CC       the same strain. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Asgard profilin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JYIM01000011; KKK46418.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0F8VPX6; -.
DR   SMR; A0A0F8VPX6; -.
DR   EnsemblBacteria; KKK46418; KKK46418; Lokiarch_01510.
DR   KEGG; loki:Lokiarch_01510; -.
DR   Proteomes; UP000034722; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   InterPro; IPR036140; PFN_sf.
DR   SUPFAM; SSF55770; SSF55770; 1.
PE   3: Inferred from homology;
KW   Actin-binding; Cytoplasm; Cytoskeleton.
FT   CHAIN           1..123
FT                   /note="Loki profilin-3"
FT                   /id="PRO_0000450551"
SQ   SEQUENCE   123 AA;  13943 MW;  E5835F5C71D168BD CRC64;
     MEEQKFHSLV KALNEHEGIE EVFLLNKDGS IIYKSGEFSL TDDEAKSILS AWKEKEPSLS
     FQNFRFAILK NDDLQLAAKN IGKGKGNIVG SITREGDYLI AHTRDEALIL LEWSIFINKV
     AWS