ID   PROF3_RAT               Reviewed;         137 AA.
AC   M0RCP6;
DT   16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2013, sequence version 1.
DT   03-AUG-2022, entry version 37.
DE   RecName: Full=Profilin-3;
DE   AltName: Full=Profilin III;
GN   Name=Pfn3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RX   PubMed=15057822; DOI=10.1038/nature02426;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC   STRAIN=Wistar; TISSUE=Testis;
RX   PubMed=15591451; DOI=10.1093/molehr/gah132;
RA   Obermann H., Raabe I., Balvers M., Brunswig B., Schulze W., Kirchhoff C.;
RT   "Novel testis-expressed profilin IV associated with acrosome biogenesis and
RT   spermatid elongation.";
RL   Mol. Hum. Reprod. 11:53-64(2005).
RN   [4]
RP   SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
RX   PubMed=19419568; DOI=10.1186/1471-2121-10-34;
RA   Behnen M., Murk K., Kursula P., Cappallo-Obermann H., Rothkegel M.,
RA   Kierszenbaum A.L., Kirchhoff C.;
RT   "Testis-expressed profilins 3 and 4 show distinct functional
RT   characteristics and localize in the acroplaxome-manchette complex in
RT   spermatids.";
RL   BMC Cell Biol. 10:34-34(2009).
CC   -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC       Slightly reduces actin polymerization. Binds to poly-L-proline,
CC       phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol
CC       4,5-bisphosphate (PtdIns(4,5)P2), and phosphatidylinositol 4-phosphate
CC       (PtdIns(4)P). May be involved in spermatogenesis. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with ACTRT3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus
CC       {ECO:0000269|PubMed:19419568}. Cytoplasm {ECO:0000269|PubMed:19419568}.
CC       Note=Localizes first in the acroplaxome and later in the manchette
CC       during spermatid head development.
CC   -!- TISSUE SPECIFICITY: Detected in round spermatids.
CC       {ECO:0000269|PubMed:15591451}.
CC   -!- DEVELOPMENTAL STAGE: Expression coincides with the increasing numbers
CC       of round spermatids and decreases during the termination of the first
CC       spermatogenic cycle. {ECO:0000269|PubMed:15591451,
CC       ECO:0000269|PubMed:19419568}.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR   EMBL; AABR06090287; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH474032; EDL93988.1; -; Genomic_DNA.
DR   RefSeq; NP_001102957.1; NM_001109487.1.
DR   AlphaFoldDB; M0RCP6; -.
DR   SMR; M0RCP6; -.
DR   STRING; 10116.ENSRNOP00000067371; -.
DR   PaxDb; M0RCP6; -.
DR   GeneID; 685936; -.
DR   KEGG; rno:685936; -.
DR   CTD; 345456; -.
DR   RGD; 1587838; Pfn3.
DR   eggNOG; ENOG502S2A3; Eukaryota.
DR   HOGENOM; CLU_123405_1_0_1; -.
DR   InParanoid; M0RCP6; -.
DR   OMA; VCVGHTP; -.
DR   OrthoDB; 1428600at2759; -.
DR   PRO; PR:M0RCP6; -.
DR   Proteomes; UP000002494; Chromosome 17.
DR   Proteomes; UP000234681; Chromosome 17.
DR   Bgee; ENSRNOG00000047752; Expressed in testis and 4 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IBA:GO_Central.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR   GO; GO:0032233; P:positive regulation of actin filament bundle assembly; IBA:GO_Central.
DR   GO; GO:0030833; P:regulation of actin filament polymerization; IBA:GO_Central.
DR   CDD; cd00148; PROF; 1.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR029893; PFN3.
DR   InterPro; IPR036140; PFN_sf.
DR   InterPro; IPR005454; Profilin1/2/3_vertebrate.
DR   PANTHER; PTHR13936:SF2; PTHR13936:SF2; 1.
DR   Pfam; PF00235; Profilin; 1.
DR   PRINTS; PR01639; PROFILINMAML.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
PE   2: Evidence at transcript level;
KW   Actin-binding; Cytoplasm; Cytoskeleton; Lipid-binding; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..137
FT                   /note="Profilin-3"
FT                   /id="PRO_0000423633"
SQ   SEQUENCE   137 AA;  14667 MW;  4D4F257834E65FC4 CRC64;
     MGDWKGYISA VLRDQRIDDV AIVGHSDNRC VWASRPGGLL AAISPQEVGV LTGPDRHTFL
     QTGLSVAGRR CCVIRDYLLA EGDGVLDART KGLDGRAICV GHTPRALLVL MGRRGVHGGI
     LNKTVHDLIG GLREQCS