ID   PROF3_TOBAC             Reviewed;         133 AA.
AC   Q9ST98;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Profilin-3;
GN   Name=PRO3;
OS   Nicotiana tabacum (Common tobacco).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC   Nicotiana.
OX   NCBI_TaxID=4097;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Petit Havana; TISSUE=Pollen;
RX   AGRICOLA=IND20526767;
RA   Mittermann I., Heiss S., Dietrich K., Valenta R., Heberle-Bors E.;
RT   "Molecular characterisation of profilin isoforms from tobacco (Nicotiana
RT   tabacum) pollen.";
RL   Sex. Plant Reprod. 9:133-139(1996).
CC   -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC       At high concentrations, profilin prevents the polymerization of actin,
CC       whereas it enhances it at low concentrations. By binding to PIP2, it
CC       inhibits the formation of IP3 and DG (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Occurs in many kinds of cells as a complex with monomeric
CC       actin in a 1:1 ratio.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR   EMBL; X93466; CAA63752.1; -; mRNA.
DR   AlphaFoldDB; Q9ST98; -.
DR   SMR; Q9ST98; -.
DR   Allergome; 1407; Nic t 8.
DR   Proteomes; UP000084051; Unplaced.
DR   GO; GO:0005938; C:cell cortex; IBA:GO_Central.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003785; F:actin monomer binding; IBA:GO_Central.
DR   GO; GO:0042989; P:sequestering of actin monomers; IBA:GO_Central.
DR   CDD; cd00148; PROF; 1.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR036140; PFN_sf.
DR   InterPro; IPR027310; Profilin_CS.
DR   PANTHER; PTHR11604; PTHR11604; 1.
DR   Pfam; PF00235; Profilin; 1.
DR   PRINTS; PR00392; PROFILIN.
DR   PRINTS; PR01640; PROFILINPLNT.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
DR   PROSITE; PS00414; PROFILIN; 1.
PE   2: Evidence at transcript level;
KW   Actin-binding; Cytoplasm; Cytoskeleton; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..133
FT                   /note="Profilin-3"
FT                   /id="PRO_0000199676"
SQ   SEQUENCE   133 AA;  14559 MW;  6EADD85F4AC867FF CRC64;
     MSWQTYVDDH LMVDFEGQGQ HLAAAAILGH DGSVWAQSPH FPKFKPEEIT NIMKDFDEPG
     FLAPTGLFLA GIKYMVIQGE PGAVIRGKKG SGGITIKKTN QALIFGLYEE PVTPGQCNMV
     VEKIGDYLVD QGY