ID   PROF4_BOVIN             Reviewed;         129 AA.
AC   Q2NKT1;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Profilin-4;
GN   Name=PFN4;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Testis;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P),
CC       phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2),
CC       phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidic acid
CC       (PA). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR   EMBL; BC111657; AAI11658.1; -; mRNA.
DR   RefSeq; NP_001068845.1; NM_001075377.2.
DR   AlphaFoldDB; Q2NKT1; -.
DR   SMR; Q2NKT1; -.
DR   STRING; 9913.ENSBTAP00000004412; -.
DR   PaxDb; Q2NKT1; -.
DR   Ensembl; ENSBTAT00000004412; ENSBTAP00000004412; ENSBTAG00000003404.
DR   GeneID; 508874; -.
DR   KEGG; bta:508874; -.
DR   CTD; 375189; -.
DR   VEuPathDB; HostDB:ENSBTAG00000003404; -.
DR   VGNC; VGNC:32778; PFN4.
DR   eggNOG; KOG1755; Eukaryota.
DR   GeneTree; ENSGT00390000017067; -.
DR   HOGENOM; CLU_120772_2_0_1; -.
DR   InParanoid; Q2NKT1; -.
DR   OMA; VMPSDVQ; -.
DR   OrthoDB; 1428600at2759; -.
DR   TreeFam; TF101075; -.
DR   Proteomes; UP000009136; Chromosome 11.
DR   Bgee; ENSBTAG00000003404; Expressed in spermatocyte and 84 other tissues.
DR   GO; GO:0005938; C:cell cortex; IBA:GO_Central.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003785; F:actin monomer binding; IBA:GO_Central.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   GO; GO:0042989; P:sequestering of actin monomers; IBA:GO_Central.
DR   CDD; cd00148; PROF; 1.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR036140; PFN_sf.
DR   PANTHER; PTHR11604; PTHR11604; 1.
DR   Pfam; PF00235; Profilin; 1.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Lipid-binding; Reference proteome.
FT   CHAIN           1..129
FT                   /note="Profilin-4"
FT                   /id="PRO_0000243935"
SQ   SEQUENCE   129 AA;  14492 MW;  650756DE5BC48E45 CRC64;
     MSHLQNLLLD TLLGTKHVDS AALIKLQERS LCVASPGFSV MPSDVRTLVN GFAKNPLKTR
     REGLYFKEKD YKCVRADDYS LYAKNENTGV IVVKTHLYLL VATYSEGMYP SVCVEATEKL
     GDYLRRKGN