ID   PROF4_HEVBR             Reviewed;         131 AA.
AC   Q9M7M9;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Profilin-4;
DE   AltName: Full=Pollen allergen Hev b 8.0202;
DE   AltName: Allergen=Hev b 8.0202;
OS   Hevea brasiliensis (Para rubber tree) (Siphonia brasiliensis).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Malpighiales; Euphorbiaceae; Crotonoideae; Micrandreae;
OC   Hevea.
OX   NCBI_TaxID=3981;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Beezhold D.H., Hickey V.L., Kostyal D.A., Sussman G.L.;
RT   "Characterization of new isoforms of the latex allergen, Hev b 8.";
RL   Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC       At high concentrations, profilin prevents the polymerization of actin,
CC       whereas it enhances it at low concentrations. By binding to PIP2, it
CC       inhibits the formation of IP3 and DG (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Occurs in many kinds of cells as a complex with monomeric
CC       actin in a 1:1 ratio.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Involved in latex
CC       allergic reactions.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR   EMBL; AF119366; AAF34342.1; -; mRNA.
DR   AlphaFoldDB; Q9M7M9; -.
DR   SMR; Q9M7M9; -.
DR   Allergome; 397; Hev b 8.
DR   Allergome; 401; Hev b 8.0202.
DR   PRIDE; Q9M7M9; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   CDD; cd00148; PROF; 1.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR036140; PFN_sf.
DR   InterPro; IPR027310; Profilin_CS.
DR   PANTHER; PTHR11604; PTHR11604; 1.
DR   Pfam; PF00235; Profilin; 1.
DR   PRINTS; PR00392; PROFILIN.
DR   PRINTS; PR01640; PROFILINPLNT.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
DR   PROSITE; PS00414; PROFILIN; 1.
PE   1: Evidence at protein level;
KW   Actin-binding; Allergen; Cytoplasm; Cytoskeleton.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..131
FT                   /note="Profilin-4"
FT                   /id="PRO_0000199636"
SQ   SEQUENCE   131 AA;  14113 MW;  B3E39216BCDD9576 CRC64;
     MSWQTYVDDH LMCDIDGHRL TAAAIIGHDG SVWAQSSSFP QFKSDEVAAI MKDFDEPGSL
     APTGLHLGST KYMVIQGEPG AVIRGKKGSG GITVKKTSQA LIIGIYDEPL TPGQCNMIVE
     RLGDYLLEQG M