ID   PROF4_MOUSE             Reviewed;         129 AA.
AC   Q9D6I3;
DT   29-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Profilin-4;
DE   AltName: Full=Profilin IV;
GN   Name=Pfn4;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Hippocampus;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   TISSUE SPECIFICITY.
RX   PubMed=15591451; DOI=10.1093/molehr/gah132;
RA   Obermann H., Raabe I., Balvers M., Brunswig B., Schulze W., Kirchhoff C.;
RT   "Novel testis-expressed profilin IV associated with acrosome biogenesis and
RT   spermatid elongation.";
RL   Mol. Hum. Reprod. 11:53-64(2005).
CC   -!- FUNCTION: Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P),
CC       phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2),
CC       phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidic acid
CC       (PA). Does not bind to actin, contrary to other family members (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Detected in testis (at protein level).
CC       {ECO:0000269|PubMed:15591451}.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AK013595; BAB28919.1; -; mRNA.
DR   CCDS; CCDS25790.1; -.
DR   RefSeq; NP_082652.1; NM_028376.3.
DR   RefSeq; XP_006515201.1; XM_006515138.2.
DR   RefSeq; XP_006515202.1; XM_006515139.2.
DR   RefSeq; XP_006515203.1; XM_006515140.2.
DR   AlphaFoldDB; Q9D6I3; -.
DR   SMR; Q9D6I3; -.
DR   STRING; 10090.ENSMUSP00000020967; -.
DR   iPTMnet; Q9D6I3; -.
DR   PhosphoSitePlus; Q9D6I3; -.
DR   PaxDb; Q9D6I3; -.
DR   PRIDE; Q9D6I3; -.
DR   ProteomicsDB; 291599; -.
DR   Antibodypedia; 27446; 48 antibodies from 15 providers.
DR   DNASU; 382562; -.
DR   Ensembl; ENSMUST00000020967; ENSMUSP00000020967; ENSMUSG00000020639.
DR   Ensembl; ENSMUST00000178879; ENSMUSP00000136765; ENSMUSG00000020639.
DR   GeneID; 382562; -.
DR   KEGG; mmu:382562; -.
DR   UCSC; uc007myf.1; mouse.
DR   CTD; 375189; -.
DR   MGI; MGI:1920121; Pfn4.
DR   VEuPathDB; HostDB:ENSMUSG00000020639; -.
DR   eggNOG; KOG1755; Eukaryota.
DR   GeneTree; ENSGT00390000017067; -.
DR   HOGENOM; CLU_120772_2_0_1; -.
DR   InParanoid; Q9D6I3; -.
DR   OMA; VMPSDVQ; -.
DR   OrthoDB; 1428600at2759; -.
DR   PhylomeDB; Q9D6I3; -.
DR   TreeFam; TF101075; -.
DR   BioGRID-ORCS; 382562; 1 hit in 73 CRISPR screens.
DR   PRO; PR:Q9D6I3; -.
DR   Proteomes; UP000000589; Chromosome 12.
DR   RNAct; Q9D6I3; protein.
DR   Bgee; ENSMUSG00000020639; Expressed in spermatid and 84 other tissues.
DR   ExpressionAtlas; Q9D6I3; baseline and differential.
DR   GO; GO:0005938; C:cell cortex; IBA:GO_Central.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003785; F:actin monomer binding; IBA:GO_Central.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   GO; GO:0042989; P:sequestering of actin monomers; IBA:GO_Central.
DR   CDD; cd00148; PROF; 1.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR036140; PFN_sf.
DR   PANTHER; PTHR11604; PTHR11604; 1.
DR   Pfam; PF00235; Profilin; 1.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Cytoskeleton; Lipid-binding; Reference proteome.
FT   CHAIN           1..129
FT                   /note="Profilin-4"
FT                   /id="PRO_0000199582"
SQ   SEQUENCE   129 AA;  14416 MW;  C33171B9F48E5B56 CRC64;
     MSHLQNLLLD TLLGTKHVDS AALIKLQEKT LCVTSPGFSV MPSDVRTLLN GFAKNPLLTR
     REGLYFKEKD YKCVRADDYS LYAKNENTGV VVVKTNMYLV VATYTAGMYP SVCVEATEKL
     GEYLRKKGN