ID   PROF_ACTDE              Reviewed;         109 AA.
AC   C0HL99;
DT   20-JUN-2018, integrated into UniProtKB/Swiss-Prot.
DT   20-JUN-2018, sequence version 1.
DT   25-MAY-2022, entry version 7.
DE   RecName: Full=Profilin {ECO:0000303|PubMed:20061012};
DE   AltName: Allergen=Act d 9 {ECO:0000303|PubMed:20061012};
DE   Flags: Fragment;
OS   Actinidia deliciosa (Kiwi).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; Ericales; Actinidiaceae; Actinidia.
OX   NCBI_TaxID=3627 {ECO:0000303|PubMed:20061012};
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND ALLERGEN.
RX   PubMed=20061012; DOI=10.1016/j.jaci.2009.10.017;
RA   Bublin M., Pfister M., Radauer C., Oberhuber C., Bulley S., Dewitt A.M.,
RA   Lidholm J., Reese G., Vieths S., Breiteneder H., Hoffmann-Sommergruber K.,
RA   Ballmer-Weber B.K.;
RT   "Component-resolved diagnosis of kiwifruit allergy with purified natural
RT   and recombinant kiwifruit allergens.";
RL   J. Allergy Clin. Immunol. 125:687-694(2010).
RN   [2] {ECO:0000305}
RP   ALLERGEN.
RX   PubMed=21083775; DOI=10.1111/j.1365-2222.2010.03619.x;
RA   Bublin M., Dennstedt S., Buchegger M., Antonietta Ciardiello M.,
RA   Bernardi M.L., Tuppo L., Harwanegg C., Hafner C., Ebner C.,
RA   Ballmer-Weber B.K., Knulst A., Hoffmann-Sommergruber K., Radauer C.,
RA   Mari A., Breiteneder H.;
RT   "The performance of a component-based allergen microarray for the diagnosis
RT   of kiwifruit allergy.";
RL   Clin. Exp. Allergy 41:129-136(2011).
CC   -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC       At high concentrations, profilin prevents the polymerization of actin,
CC       whereas it enhances it at low concentrations. By binding to PIP2, it
CC       inhibits the formation of IP3 and DG. {ECO:0000250|UniProtKB:P35081}.
CC   -!- SUBUNIT: Multimer. Occurs in many kinds of cells as a complex with
CC       monomeric actin in a 1:1 ratio. {ECO:0000250|UniProtKB:P35081}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:P35081}.
CC   -!- ALLERGEN: Causes an allergic reaction in human (PubMed:20061012,
CC       PubMed:21083775). Binds to IgE (PubMed:20061012, PubMed:21083775).
CC       {ECO:0000269|PubMed:20061012, ECO:0000269|PubMed:21083775}.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR   EMBL; FG438715; -; NOT_ANNOTATED_CDS; mRNA.
DR   AlphaFoldDB; C0HL99; -.
DR   SMR; C0HL99; -.
DR   Allergome; 5740; Act d 9.
DR   Allergome; 5741; Act d 9.0101.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   CDD; cd00148; PROF; 1.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR036140; PFN_sf.
DR   InterPro; IPR027310; Profilin_CS.
DR   PANTHER; PTHR11604; PTHR11604; 1.
DR   Pfam; PF00235; Profilin; 1.
DR   PRINTS; PR00392; PROFILIN.
DR   PRINTS; PR01640; PROFILINPLNT.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
DR   PROSITE; PS00414; PROFILIN; 1.
PE   1: Evidence at protein level;
KW   Actin-binding; Allergen; Cytoplasm; Cytoskeleton; Disulfide bond.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q8H2C9"
FT   CHAIN           2..>109
FT                   /note="Profilin"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000444429"
FT   DISULFID        13..?
FT                   /evidence="ECO:0000250|UniProtKB:P35081"
FT   NON_TER         109
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   109 AA;  11700 MW;  02D9A417DBDBEF4B CRC64;
     MSWQTYVDDH LMCEIEGNYL TSAAIIGQDG SIWAQSASFP QFKPEEITAI MNDFSEPGTL
     APTGLYLGGT KYMVIQGEAG AVIRGKKGPG GVTVKKTNQA LIIGIYDEP