PROF_ANACO
ID PROF_ANACO Reviewed; 131 AA.
AC Q94JN2;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 25-MAY-2022, entry version 59.
DE RecName: Full=Profilin;
DE AltName: Full=Minor food allergen Ana c 1;
DE AltName: Allergen=Ana c 1;
OS Ananas comosus (Pineapple) (Ananas ananas).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Bromeliaceae;
OC Bromelioideae; Ananas.
OX NCBI_TaxID=4615;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND ALLERGEN.
RX PubMed=12065910; DOI=10.1159/000059400;
RA Reindl J., Rihs H.P., Scheurer S., Wangorsch A., Haustein D., Vieths S.;
RT "IgE reactivity to profilin in pollen-sensitized subjects with adverse
RT reactions to banana and pineapple.";
RL Int. Arch. Allergy Immunol. 128:105-114(2002).
CC -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC At high concentrations, profilin prevents the polymerization of actin,
CC whereas it enhances it at low concentrations. By binding to PIP2, it
CC inhibits the formation of IP3 and DG (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Occurs in many kinds of cells as a complex with monomeric
CC actin in a 1:1 ratio.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC -!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE. This is a
CC food allergen. {ECO:0000269|PubMed:12065910}.
CC -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR EMBL; AF377949; AAK54835.1; -; mRNA.
DR RefSeq; XP_020097077.1; XM_020241488.1.
DR AlphaFoldDB; Q94JN2; -.
DR SMR; Q94JN2; -.
DR Allergome; 3075; Ana c 1.0101.
DR Allergome; 33; Ana c 1.
DR GeneID; 109716166; -.
DR OrthoDB; 1428600at2759; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR CDD; cd00148; PROF; 1.
DR InterPro; IPR005455; PFN.
DR InterPro; IPR036140; PFN_sf.
DR InterPro; IPR027310; Profilin_CS.
DR PANTHER; PTHR11604; PTHR11604; 1.
DR Pfam; PF00235; Profilin; 1.
DR PRINTS; PR00392; PROFILIN.
DR PRINTS; PR01640; PROFILINPLNT.
DR SMART; SM00392; PROF; 1.
DR SUPFAM; SSF55770; SSF55770; 1.
DR PROSITE; PS00414; PROFILIN; 1.
PE 1: Evidence at protein level;
KW Actin-binding; Allergen; Cytoplasm; Cytoskeleton.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..131
FT /note="Profilin"
FT /id="PRO_0000199612"
SQ SEQUENCE 131 AA; 14229 MW; D3C05FC6B70ABD98 CRC64;
MSWQAYVDDH LMCEIDGQHL SSAAILGHDS TVWAQSPNFP QFKPEEISAI LNDFENPGSL
APTGLYLGGT KYMVIQGEPG VVIRGKKGTG GITVKKTNLA LIIGVYDEPM TPGQCNMVVE
RLGDYLLEQG F