ID   PROF_APIGR              Reviewed;         134 AA.
AC   Q9XF37;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Profilin;
DE   AltName: Full=Minor pollen allergen Api g 4;
DE   AltName: Allergen=Api g 4;
OS   Apium graveolens (Celery).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; campanulids; Apiales; Apiaceae; Apioideae; apioid superclade;
OC   Apieae; Apium.
OX   NCBI_TaxID=4045;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND ALLERGEN.
RC   STRAIN=cv. Prinz;
RX   PubMed=10848918; DOI=10.1046/j.1365-2222.2000.00821.x;
RA   Scheurer S., Wangorsch A., Haustein D., Vieths S.;
RT   "Cloning of the minor allergen Api g 4 profilin from celery (Apium
RT   graveolens) and its cross-reactivity with birch pollen profilin Bet v 2.";
RL   Clin. Exp. Allergy 30:962-971(2000).
CC   -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC       At high concentrations, profilin prevents the polymerization of actin,
CC       whereas it enhances it at low concentrations. By binding to PIP2, it
CC       inhibits the formation of IP3 and DG (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Occurs in many kinds of cells as a complex with monomeric
CC       actin in a 1:1 ratio.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- ALLERGEN: Causes an allergic reaction in human.
CC       {ECO:0000269|PubMed:10848918}.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR   EMBL; AF129423; AAD29409.1; -; mRNA.
DR   AlphaFoldDB; Q9XF37; -.
DR   SMR; Q9XF37; -.
DR   Allergome; 43; Api g 4.
DR   Allergome; 5996; Api g 4.0101.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   CDD; cd00148; PROF; 1.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR036140; PFN_sf.
DR   InterPro; IPR027310; Profilin_CS.
DR   PANTHER; PTHR11604; PTHR11604; 1.
DR   Pfam; PF00235; Profilin; 1.
DR   PRINTS; PR00392; PROFILIN.
DR   PRINTS; PR01640; PROFILINPLNT.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
DR   PROSITE; PS00414; PROFILIN; 1.
PE   1: Evidence at protein level;
KW   Actin-binding; Allergen; Cytoplasm; Cytoskeleton.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..134
FT                   /note="Profilin"
FT                   /id="PRO_0000199613"
SQ   SEQUENCE   134 AA;  14276 MW;  5246BCC865C1DC57 CRC64;
     MSWQAYVDDH LMCEVEGNPG QTLTAAAIIG HDGSVWAQSS TFPQIKPEEI AGIMKDFDEP
     GHLAPTGLYL GGAKYMVIQG EPNAVIRGKK GSGGVTIKKT GQALVFGVYD EPVTPGQCNV
     IVERLGDYLI DQGL