位置:首页 > 蛋白库 > PROF_APIME
PROF_APIME
ID   PROF_APIME              Reviewed;         126 AA.
AC   Q6QEJ7;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Profilin;
OS   Apis mellifera (Honeybee).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea; Apidae;
OC   Apis.
OX   NCBI_TaxID=7460;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Kucharski R., Maleszka R.;
RL   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC       At high concentrations, profilin prevents the polymerization of actin,
CC       whereas it enhances it at low concentrations. By binding to PIP2, it
CC       inhibits the formation of IP3 and DG (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Occurs in many kinds of cells as a complex with monomeric
CC       actin in a 1:1 ratio. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY545000; AAS50159.2; -; mRNA.
DR   RefSeq; NP_001011626.2; NM_001011626.2.
DR   AlphaFoldDB; Q6QEJ7; -.
DR   SMR; Q6QEJ7; -.
DR   STRING; 7460.GB40389-PA; -.
DR   PaxDb; Q6QEJ7; -.
DR   GeneID; 406154; -.
DR   KEGG; ame:406154; -.
DR   CTD; 406154; -.
DR   eggNOG; KOG1755; Eukaryota.
DR   OrthoDB; 1428600at2759; -.
DR   Proteomes; UP000005203; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   CDD; cd00148; PROF; 1.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR036140; PFN_sf.
DR   PANTHER; PTHR11604; PTHR11604; 1.
DR   Pfam; PF00235; Profilin; 1.
DR   PRINTS; PR00392; PROFILIN.
DR   PRINTS; PR01640; PROFILINPLNT.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
PE   2: Evidence at transcript level;
KW   Actin-binding; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..126
FT                   /note="Profilin"
FT                   /id="PRO_0000199587"
SQ   SEQUENCE   126 AA;  13720 MW;  1EF69E60FC1FDE65 CRC64;
     MSCQDYVDKQ LLASRCVTKA AIAGHDGNLW AKSEGFEVSK EELTKLVQGF EEQDILTSSG
     VTLAGNRYIY LSGTDRVIRA KLGKVGVHCM KTTQAVVVSL YEDPIQPQQA ASVVEKLGDY
     LVSCGY
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024