ID   PROF_ARAHY              Reviewed;         131 AA.
AC   Q9SQI9;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Profilin;
DE   AltName: Allergen=Ara h 5;
OS   Arachis hypogaea (Peanut).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC   dalbergioids sensu lato; Dalbergieae; Pterocarpus clade; Arachis.
OX   NCBI_TaxID=3818;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND ALLERGEN.
RC   STRAIN=cv. Virginia; TISSUE=Seed;
RX   PubMed=10474031; DOI=10.1159/000024203;
RA   Kleber-Janke T., Crameri R., Appenzeller U., Schlaak M., Becker W.-M.;
RT   "Selective cloning of peanut allergens, including profilin and 2S albumins,
RT   by phage display technology.";
RL   Int. Arch. Allergy Immunol. 119:265-274(1999).
CC   -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC       At high concentrations, profilin prevents the polymerization of actin,
CC       whereas it enhances it at low concentrations. By binding to PIP2, it
CC       inhibits the formation of IP3 and DG (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Occurs in many kinds of cells as a complex with monomeric
CC       actin in a 1:1 ratio.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- ALLERGEN: Causes an allergic reaction in human.
CC       {ECO:0000269|PubMed:10474031}.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR   EMBL; AF059616; AAD55587.1; -; mRNA.
DR   AlphaFoldDB; Q9SQI9; -.
DR   SMR; Q9SQI9; -.
DR   Allergome; 3097; Ara h 5.0101.
DR   Allergome; 54; Ara h 5.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   CDD; cd00148; PROF; 1.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR036140; PFN_sf.
DR   InterPro; IPR027310; Profilin_CS.
DR   PANTHER; PTHR11604; PTHR11604; 1.
DR   Pfam; PF00235; Profilin; 1.
DR   PRINTS; PR00392; PROFILIN.
DR   PRINTS; PR01640; PROFILINPLNT.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
DR   PROSITE; PS00414; PROFILIN; 1.
PE   1: Evidence at protein level;
KW   Actin-binding; Allergen; Cytoplasm; Cytoskeleton.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..131
FT                   /note="Profilin"
FT                   /id="PRO_0000199614"
SQ   SEQUENCE   131 AA;  14051 MW;  05C17151B1BBBA74 CRC64;
     MSWQTYVDNH LLCEIEGDHL SSAAILGQDG GVWAQSSHFP QFKPEEITAI MNDFAEPGSL
     APTGLYLGGT KYMVIQGEPG AIIPGKKGPG GVTIEKTNQA LIIGIYDKPM TPGQCNMIVE
     RLGDYLIDTG L