ID   PROF_BETVU              Reviewed;          23 AA.
AC   P85984;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 21.
DE   RecName: Full=Profilin {ECO:0000250|UniProtKB:P25816};
DE   AltName: Full=Pollen allergen Beta v 2 {ECO:0000303|PubMed:18694503};
DE   AltName: Allergen=Beta v 2 {ECO:0000303|PubMed:18694503};
DE   Flags: Fragments;
OS   Beta vulgaris (Sugar beet).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   Caryophyllales; Chenopodiaceae; Betoideae; Beta.
OX   NCBI_TaxID=161934;
RN   [1]
RP   PROTEIN SEQUENCE, AND ALLERGEN.
RC   TISSUE=Pollen;
RX   PubMed=18694503; DOI=10.1186/1476-7961-6-7;
RA   Luoto S., Lambert W., Blomqvist A., Emanuelsson C.;
RT   "The identification of allergen proteins in sugar beet (Beta vulgaris)
RT   pollen causing occupational allergy in greenhouses.";
RL   Clin. Mol. Allergy 6:7-7(2008).
CC   -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC       At high concentrations, profilin prevents the polymerization of actin,
CC       whereas it enhances it at low concentrations. By binding to PIP2, it
CC       inhibits the formation of IP3 and DG (By similarity).
CC       {ECO:0000250|UniProtKB:P25816}.
CC   -!- SUBUNIT: Occurs in many kinds of cells as a complex with monomeric
CC       actin in a 1:1 ratio. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:P25816}.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE.
CC       {ECO:0000269|PubMed:18694503}.
CC   -!- MISCELLANEOUS: On the 2D-gel the determined pI of this protein is: 4.5,
CC       its MW is: 14 kDa. {ECO:0000269|PubMed:18694503}.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000255}.
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DR   AlphaFoldDB; P85984; -.
DR   Allergome; 5799; Beta v 2.
DR   Allergome; 5815; Beta v 2.0101.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Actin-binding; Allergen; Cytoplasm; Cytoskeleton;
KW   Direct protein sequencing.
FT   CHAIN           <1..>23
FT                   /note="Profilin"
FT                   /id="PRO_0000349146"
FT   NON_CONS        13..14
FT                   /evidence="ECO:0000303|PubMed:18694503"
FT   NON_TER         1
FT                   /evidence="ECO:0000303|PubMed:18694503"
FT   NON_TER         23
FT                   /evidence="ECO:0000303|PubMed:18694503"
SQ   SEQUENCE   23 AA;  2521 MW;  76F45B830CB79CDF CRC64;
     YMVIQGEPGA VIRLGDYLID QGL