ID   PROF_BOMMO              Reviewed;         126 AA.
AC   Q68HB4;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Profilin;
OS   Bombyx mori (Silk moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Bombycidae; Bombycinae; Bombyx.
OX   NCBI_TaxID=7091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Wei Y., Choi Y., Jin B.;
RT   "Molecular cloning of a profilin cDNA from Bombyx mori.";
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC       At high concentrations, profilin prevents the polymerization of actin,
CC       whereas it enhances it at low concentrations. By binding to PIP2, it
CC       inhibits the formation of IP3 and DG (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Occurs in many kinds of cells as a complex with monomeric
CC       actin in a 1:1 ratio. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR   EMBL; AY690617; AAT99314.1; -; mRNA.
DR   RefSeq; NP_001037108.1; NM_001043643.1.
DR   AlphaFoldDB; Q68HB4; -.
DR   SMR; Q68HB4; -.
DR   STRING; 7091.BGIBMGA002981-TA; -.
DR   EnsemblMetazoa; BGIBMGA002981-RA; BGIBMGA002981-TA; BGIBMGA002981.
DR   GeneID; 692652; -.
DR   KEGG; bmor:692652; -.
DR   CTD; 692652; -.
DR   eggNOG; KOG1755; Eukaryota.
DR   HOGENOM; CLU_120772_0_1_1; -.
DR   InParanoid; Q68HB4; -.
DR   OMA; TIQPAEM; -.
DR   OrthoDB; 1428600at2759; -.
DR   Proteomes; UP000005204; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0044087; P:regulation of cellular component biogenesis; IEA:UniProt.
DR   GO; GO:0051128; P:regulation of cellular component organization; IEA:UniProt.
DR   CDD; cd00148; PROF; 1.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR036140; PFN_sf.
DR   InterPro; IPR027310; Profilin_CS.
DR   PANTHER; PTHR11604; PTHR11604; 1.
DR   Pfam; PF00235; Profilin; 1.
DR   PRINTS; PR00392; PROFILIN.
DR   PRINTS; PR01640; PROFILINPLNT.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
DR   PROSITE; PS00414; PROFILIN; 1.
PE   2: Evidence at transcript level;
KW   Actin-binding; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..126
FT                   /note="Profilin"
FT                   /id="PRO_0000199588"
SQ   SEQUENCE   126 AA;  13713 MW;  E85E94F9253E3215 CRC64;
     MSWQDYVDKQ LMASRCVTKA AIAGHDGNVW AKSEGFEISK DEVAKIVAGF ENESLLTSGG
     VTIAGTRYIY LSGTDHIIRA KLGKVGVHCM KTQQAVVISL YEEPIQPQQA ASVVEKLGEY
     LITCGY