ID   PROF_BRANA              Reviewed;         134 AA.
AC   Q9FUB8;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Profilin;
OS   Brassica napus (Rape).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Brassica.
OX   NCBI_TaxID=3708;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pollen;
RA   Ye Q., Li X.F., Xu Y., Wang J., Ling J., Chen F.;
RT   "Cloning and expression of profilin gene from rapeseed pollen.";
RL   Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC       At high concentrations, profilin prevents the polymerization of actin,
CC       whereas it enhances it at low concentrations. By binding to PIP2, it
CC       inhibits the formation of IP3 and DG (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Occurs in many kinds of cells as a complex with monomeric
CC       actin in a 1:1 ratio.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR   EMBL; AF315326; AAG33237.1; -; mRNA.
DR   RefSeq; XP_013667672.1; XM_013812218.1.
DR   AlphaFoldDB; Q9FUB8; -.
DR   SMR; Q9FUB8; -.
DR   Allergome; 1073; Bra n 8.
DR   GeneID; 106372089; -.
DR   KEGG; bna:106372089; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   CDD; cd00148; PROF; 1.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR036140; PFN_sf.
DR   InterPro; IPR027310; Profilin_CS.
DR   PANTHER; PTHR11604; PTHR11604; 1.
DR   Pfam; PF00235; Profilin; 1.
DR   PRINTS; PR00392; PROFILIN.
DR   PRINTS; PR01640; PROFILINPLNT.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
DR   PROSITE; PS00414; PROFILIN; 1.
PE   2: Evidence at transcript level;
KW   Actin-binding; Cytoplasm; Cytoskeleton.
FT   CHAIN           1..134
FT                   /note="Profilin"
FT                   /id="PRO_0000199623"
SQ   SEQUENCE   134 AA;  14459 MW;  478FC7EEBCE155A7 CRC64;
     MSWQTYVDEH LMCDVGDGQG HHLAAAAIFG HDGSVWAQSA NFPQFKGQEF ANIMKDFDEP
     GHLAPTGLFL AGAKYMVIQG EPGAVIRGKK GAGGITIKKT GQSCVFGIYE EPVTPGQCNM
     VVERLGDYLI EQDL