ID   PROF_CANAX              Reviewed;         126 AA.
AC   P53696;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Profilin;
GN   Name=PFY1;
OS   Candida albicans (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=5476;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9234675;
RX   DOI=10.1002/(sici)1097-0061(199707)13:9<871::aid-yea127>3.0.co;2-2;
RA   Ostrander D.B., Gorman J.A.;
RT   "Isolation and characterization of the Candida albicans PFY1 gene for
RT   profilin.";
RL   Yeast 13:871-880(1997).
CC   -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC       At high concentrations, profilin prevents the polymerization of actin,
CC       whereas it enhances it at low concentrations. By binding to PIP2, it
CC       inhibits the formation of IP3 and DG.
CC   -!- SUBUNIT: Occurs in many kinds of cells as a complex with monomeric
CC       actin in a 1:1 ratio.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR   EMBL; L37834; AAB68316.1; -; Genomic_DNA.
DR   AlphaFoldDB; P53696; -.
DR   SMR; P53696; -.
DR   VEuPathDB; FungiDB:C1_08030W_A; -.
DR   VEuPathDB; FungiDB:CAWG_00619; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   CDD; cd00148; PROF; 1.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR036140; PFN_sf.
DR   InterPro; IPR027310; Profilin_CS.
DR   PANTHER; PTHR11604; PTHR11604; 1.
DR   Pfam; PF00235; Profilin; 1.
DR   PRINTS; PR00392; PROFILIN.
DR   PRINTS; PR01640; PROFILINPLNT.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
DR   PROSITE; PS00414; PROFILIN; 1.
PE   3: Inferred from homology;
KW   Actin-binding; Cytoplasm; Cytoskeleton.
FT   CHAIN           1..126
FT                   /note="Profilin"
FT                   /id="PRO_0000199606"
SQ   SEQUENCE   126 AA;  13821 MW;  45B332306E573B73 CRC64;
     MSWQAYIDNL IANGKVDKAA LYSRAGDALW AQSGSFELQQ PEITEIAKGF DSAEGLQTSG
     LHVQGQKYFL LRADDRSIYG KHEAEGVICV RTKQTILIAH YPSGVQPGEA TTLVEKLADY
     LINVGY