ID   PROF_CAPAN              Reviewed;         131 AA.
AC   Q93YI9;
DT   24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Profilin;
DE   AltName: Full=Minor food allergen Cap a 2;
DE   AltName: Allergen=Cap a 2;
OS   Capsicum annuum (Capsicum pepper).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Capsiceae; Capsicum.
OX   NCBI_TaxID=4072;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND ALLERGEN.
RC   TISSUE=Fruit;
RX   PubMed=12915767; DOI=10.1159/000072136;
RA   Willerroider M., Fuchs H., Ballmer-Weber B., Focke M., Susani M.,
RA   Thalhamer J., Ferreira F., Wuethrich B., Scheiner O., Breiteneder H.,
RA   Hoffman-Sommergruber K.;
RT   "Cloning and molecular and immunological characterization of two new food
RT   allergens, Cap a 2 and Lyc e 1, profilins from bell pepper (Capsicum
RT   annuum) and Tomato (Lycopersicon esculentum).";
RL   Int. Arch. Allergy Immunol. 131:245-255(2003).
CC   -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC       At high concentrations, profilin prevents the polymerization of actin,
CC       whereas it enhances it at low concentrations. By binding to PIP2, it
CC       inhibits the formation of IP3 and DG (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Occurs in many kinds of cells as a complex with monomeric
CC       actin in a 1:1 ratio.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE. This is a
CC       food allergen. {ECO:0000269|PubMed:12915767}.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR   EMBL; AJ417552; CAD10376.1; -; mRNA.
DR   AlphaFoldDB; Q93YI9; -.
DR   SMR; Q93YI9; -.
DR   Allergome; 3177; Cap a 2.0101.
DR   Allergome; 689; Cap a 2.
DR   EnsemblPlants; PHT69404; PHT69404; T459_28891.
DR   Gramene; PHT69404; PHT69404; T459_28891.
DR   OMA; NETMSWQ; -.
DR   Proteomes; UP000189700; Genome assembly.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   CDD; cd00148; PROF; 1.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR036140; PFN_sf.
DR   InterPro; IPR027310; Profilin_CS.
DR   PANTHER; PTHR11604; PTHR11604; 1.
DR   Pfam; PF00235; Profilin; 1.
DR   PRINTS; PR00392; PROFILIN.
DR   PRINTS; PR01640; PROFILINPLNT.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
DR   PROSITE; PS00414; PROFILIN; 1.
PE   1: Evidence at protein level;
KW   Actin-binding; Allergen; Cytoplasm; Cytoskeleton.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..131
FT                   /note="Profilin"
FT                   /id="PRO_0000199624"
SQ   SEQUENCE   131 AA;  14184 MW;  E59E0C47D1D3F487 CRC64;
     MSWQTYVDDH LMCEIEGNRL TSAAIIGQDG SVWAQSATFP QFKPEEITAI MNDFAEPGTL
     APTGLYLGGT KYMVIQGEAG AVIRGKKGPG GITVKKTNQA LIIGIYDEPM TPGQCNMIVE
     RLGDYLIEQS L