ID   PROF_CHEAL              Reviewed;         131 AA.
AC   Q84V37;
DT   24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Profilin;
DE   AltName: Full=Minor pollen allergen Che a 2;
DE   AltName: Allergen=Che a 2;
OS   Chenopodium album (Fat-hen).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   Caryophyllales; Chenopodiaceae; Chenopodioideae; Atripliceae; Chenopodium.
OX   NCBI_TaxID=3559;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND ALLERGEN.
RC   TISSUE=Pollen;
RX   PubMed=15208604; DOI=10.1016/j.jaci.2003.12.587;
RA   Barderas R., Villalba M., Pascual C.Y., Batanero E., Rodriguez R.;
RT   "Profilin (Che a 2) and polcalcin (Che a 3) are relevant allergens of
RT   Chenopodium album pollen: isolation, amino acid sequences, and immunologic
RT   properties.";
RL   J. Allergy Clin. Immunol. 113:1192-1198(2004).
CC   -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC       At high concentrations, profilin prevents the polymerization of actin,
CC       whereas it enhances it at low concentrations. By binding to PIP2, it
CC       inhibits the formation of IP3 and DG (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Occurs in many kinds of cells as a complex with monomeric
CC       actin in a 1:1 ratio.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE.
CC       {ECO:0000269|PubMed:15208604}.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR   EMBL; AY082337; AAL92870.1; -; mRNA.
DR   AlphaFoldDB; Q84V37; -.
DR   SMR; Q84V37; -.
DR   Allergome; 1068; Che a 2.
DR   Allergome; 3189; Che a 2.0101.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   CDD; cd00148; PROF; 1.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR036140; PFN_sf.
DR   InterPro; IPR027310; Profilin_CS.
DR   PANTHER; PTHR11604; PTHR11604; 1.
DR   Pfam; PF00235; Profilin; 1.
DR   PRINTS; PR00392; PROFILIN.
DR   PRINTS; PR01640; PROFILINPLNT.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
DR   PROSITE; PS00414; PROFILIN; 1.
PE   1: Evidence at protein level;
KW   Actin-binding; Allergen; Cytoplasm; Cytoskeleton.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..131
FT                   /note="Profilin"
FT                   /id="PRO_0000199625"
SQ   SEQUENCE   131 AA;  14099 MW;  85BEAEC83ADA7F85 CRC64;
     MSWQTYVDDH LMCDIEGNHL SSAAILGHDG TVWAQSPSFP QLKPEEVSAI MKDFNEPGSL
     APTGLHLGGT KYMVIQGEPG DVIRGKKGPG GVTIKKTNQA LIIGIYGEPM TPGQCNMVVE
     RIGDYLVEQG M