ID   PROF_DAUCA              Reviewed;         134 AA.
AC   Q8SAE6;
DT   24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Profilin;
DE   AltName: Full=Minor pollen allergen Dau c 4;
DE   AltName: Allergen=Dau c 4;
OS   Daucus carota (Wild carrot).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; campanulids; Apiales; Apiaceae; Apioideae; Scandiceae; Daucinae;
OC   Daucus; Daucus sect. Daucus.
OX   NCBI_TaxID=4039;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Vieths S., Wangorsch A., Ballmer-Weber B.K.;
RT   "Molecular characterization of Dau c 4 (profilin), a minor allergen from
RT   carrot.";
RL   Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC       At high concentrations, profilin prevents the polymerization of actin,
CC       whereas it enhances it at low concentrations. By binding to PIP2, it
CC       inhibits the formation of IP3 and DG (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Occurs in many kinds of cells as a complex with monomeric
CC       actin in a 1:1 ratio.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- ALLERGEN: Causes an allergic reaction in human.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR   EMBL; AF456482; AAL76933.1; -; mRNA.
DR   AlphaFoldDB; Q8SAE6; -.
DR   SMR; Q8SAE6; -.
DR   Allergome; 3245; Dau c 4.0101.
DR   Allergome; 692; Dau c 4.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   CDD; cd00148; PROF; 1.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR036140; PFN_sf.
DR   InterPro; IPR027310; Profilin_CS.
DR   PANTHER; PTHR11604; PTHR11604; 1.
DR   Pfam; PF00235; Profilin; 1.
DR   PRINTS; PR00392; PROFILIN.
DR   PRINTS; PR01640; PROFILINPLNT.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
DR   PROSITE; PS00414; PROFILIN; 1.
PE   1: Evidence at protein level;
KW   Actin-binding; Allergen; Cytoplasm; Cytoskeleton.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..134
FT                   /note="Profilin"
FT                   /id="PRO_0000199630"
SQ   SEQUENCE   134 AA;  14425 MW;  5F3A521ED6B5FBA7 CRC64;
     MSWQTYVDDH LMCEVDGNPG QQLSAAAIIG HDGSVWAQSS TFPKFKPEEI TGIMKNFDEP
     GHLAPTGLYL GGTKYMVIQG EPIAVIRGKK GSGGVTIKKT GQALVFGVYD EPVTPGQCNL
     IVERLGDYLI EQGL