AAC1_DICDI
ID AAC1_DICDI Reviewed; 797 AA.
AC P14195; Q54E23;
DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 2.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=Leucine-rich repeat-containing protein AAC1;
DE AltName: Full=AAC-rich mRNA clone AAC1 protein;
GN Name=AAC1; ORFNames=DDB_G0291860;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 60-248, AND DEVELOPMENTAL STAGE.
RX PubMed=2511421; DOI=10.1007/bf00332409;
RA Shaw D.R., Richter H., Giorda R., Ohmachi T., Ennis H.L.;
RT "Nucleotide sequences of Dictyostelium discoideum developmentally regulated
RT cDNAs rich in (AAC) imply proteins that contain clusters of asparagine,
RT glutamine, or threonine.";
RL Mol. Gen. Genet. 218:453-459(1989).
CC -!- DEVELOPMENTAL STAGE: The concentration of AAC-rich mRNAs is low in
CC dormant spores and growing cells, but increases during spore-
CC germination and multicellular development.
CC {ECO:0000269|PubMed:2511421}.
CC -!- MISCELLANEOUS: Several proteins derive from AAC-rich mRNA, which, due
CC to a frameshift also have ACA and CAA codons and thus are Asn-, Thr- or
CC Gln-rich.
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DR EMBL; AAFI02000186; EAL61460.1; -; Genomic_DNA.
DR EMBL; X16525; CAA34532.1; -; mRNA.
DR PIR; S05358; S05358.
DR RefSeq; XP_629873.1; XM_629871.1.
DR AlphaFoldDB; P14195; -.
DR SMR; P14195; -.
DR STRING; 44689.DDB0201568; -.
DR PaxDb; P14195; -.
DR EnsemblProtists; EAL61460; EAL61460; DDB_G0291860.
DR GeneID; 8628371; -.
DR KEGG; ddi:DDB_G0291860; -.
DR dictyBase; DDB_G0291860; -.
DR eggNOG; KOG4308; Eukaryota.
DR HOGENOM; CLU_352838_0_0_1; -.
DR InParanoid; P14195; -.
DR OMA; ISYSEFY; -.
DR Reactome; R-DDI-168638; NOD1/2 Signaling Pathway.
DR PRO; PR:P14195; -.
DR Proteomes; UP000002195; Chromosome 6.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13516; LRR_6; 4.
PE 2: Evidence at transcript level;
KW Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..797
FT /note="Leucine-rich repeat-containing protein AAC1"
FT /id="PRO_0000064408"
FT REPEAT 376..397
FT /note="LRR 1"
FT REPEAT 406..425
FT /note="LRR 2"
FT REPEAT 435..456
FT /note="LRR 3"
FT REPEAT 464..484
FT /note="LRR 4"
FT REPEAT 492..513
FT /note="LRR 5"
FT REPEAT 514..535
FT /note="LRR 6"
FT REPEAT 543..564
FT /note="LRR 7"
FT REPEAT 572..593
FT /note="LRR 8"
FT REPEAT 601..622
FT /note="LRR 9"
FT REPEAT 633..653
FT /note="LRR 10"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 51..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 125..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 307..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..329
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 141..146
FT /note="Missing (in Ref. 2; CAA34532)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 797 AA; 89497 MW; 0CCB0676C5C581FF CRC64;
MKRTSNRNEE ATAKLSSSTT ITTTTTNKYY NMANAEKSSK STTISNLIPK YSLFNEPNND
NDTNSSTRPN KQQKLLKSNE STTSTTTTTT PITTTTTTTT TTTTPNLSKY YNYNLYIEKQ
NEKQNLPTTE TETTTITPTL TTTTTTTTTT TTTTTKQIQN TTTSTINHFL PLIIQKEIIF
LLVELGSFLN ARKVCKYWKK VCNGCVENLN IYFTDIHLSA SVKHVSEVFV KSLNSDYFHL
QSVSFINGAK NSISYSEFYF NNVILPFIEN VVRYNQTIEN FTIKGFPITR INNKSSQQLL
PSYKLYHSTS VPSSPPPPPP PPPPQIQQPT ITAPTSTTAI AVSSTTTTAT GQTLNNNNNN
NNIPKGLNYY LTNNFKLKKI NLKNIGLDSR DKFDFFSSLS SSVNNTLETL IICDNIGDEG
MQLLSVILIK NLLKVLKRLE LQKNQFTNQS AYYLNKVLSC EQLQLETLNL SSNRIDEQGL
IMMKDGFGRN KSLKEFIFSK NRLGNTDSVD FGKSITSLDL HDSMVGSKQS IKGLSQYLKF
NESITSLNLS FNHIGSNEAI KSLSKSFAVN QTLKFVDLSF NKINSNFGLD HLVSSLLINH
SIHSISLQSN QIDNTSAITL SQLFNSSRQL FSPFKYLNLS GNKIGIGGLK KLINDLSKYS
KTHIIYNNND DNNNNKNENE NKSKIKNLSF NNNNNNFVKI IKNYHDTIPI IRTINNSNGK
NLLEEEVEQV INSSSNDTNQ NDNINNENNL TEISIDLSSN SPLEVSKVIG LIPRYKSKLT
FADRKPVKKY KLVKLLF
