ID   PROF_ENTHI              Reviewed;         130 AA.
AC   P49230;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Profilin;
OS   Entamoeba histolytica.
OC   Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC   Entamoeba.
OX   NCBI_TaxID=5759;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 74-84 AND 86-94.
RC   STRAIN=SFL-3;
RX   PubMed=8521867; DOI=10.1111/j.1432-1033.1995.976_3.x;
RA   Binder M., Ortner S., Erben H., Scheiner O., Wiedermann G., Valenta R.,
RA   Duchene M.;
RT   "The basic isoform of profilin in pathogenic Entamoeba histolytica. cDNA
RT   cloning, heterologous expression, and actin-binding properties.";
RL   Eur. J. Biochem. 233:976-981(1995).
CC   -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC       At high concentrations, profilin prevents the polymerization of actin,
CC       whereas it enhances it at low concentrations. By binding to PIP2, it
CC       inhibits the formation of IP3 and DG.
CC   -!- SUBUNIT: Occurs in many kinds of cells as a complex with monomeric
CC       actin in a 1:1 ratio.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR   EMBL; X90911; CAA62418.1; -; mRNA.
DR   PIR; S63533; S63533.
DR   AlphaFoldDB; P49230; -.
DR   SMR; P49230; -.
DR   STRING; 5759.rna_EHI_176140-1; -.
DR   VEuPathDB; AmoebaDB:EHI5A_101680; -.
DR   VEuPathDB; AmoebaDB:EHI7A_063630; -.
DR   VEuPathDB; AmoebaDB:EHI8A_066600; -.
DR   VEuPathDB; AmoebaDB:EHI_176140; -.
DR   VEuPathDB; AmoebaDB:KM1_121210; -.
DR   eggNOG; KOG1755; Eukaryota.
DR   OMA; WAQSSGF; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   CDD; cd00148; PROF; 1.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR036140; PFN_sf.
DR   InterPro; IPR027310; Profilin_CS.
DR   PANTHER; PTHR11604; PTHR11604; 1.
DR   Pfam; PF00235; Profilin; 1.
DR   PRINTS; PR01640; PROFILINPLNT.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
DR   PROSITE; PS00414; PROFILIN; 1.
PE   1: Evidence at protein level;
KW   Actin-binding; Cytoplasm; Cytoskeleton; Direct protein sequencing.
FT   CHAIN           1..130
FT                   /note="Profilin"
FT                   /id="PRO_0000199598"
SQ   SEQUENCE   130 AA;  13237 MW;  AF50A8E08FA00A6F CRC64;
     MSWQSYVDSF LVGAGKGMGG AIIGLQGGVW AASANCTPSA QESVAIGTAC ASNIAGLQQT
     GVVIGGKKYM ITRVDADEGT AMGKKGAEGI SIYKTKQAVI IGYFSDASVS AGQNSDATYK
     CAKYLMDAGY