ID   PROF_FRAAN              Reviewed;         131 AA.
AC   P0C0Y3;
DT   24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   25-MAY-2022, entry version 47.
DE   RecName: Full=Profilin;
DE   AltName: Allergen=Fra a 4;
OS   Fragaria ananassa (Strawberry) (Fragaria chiloensis x Fragaria virginiana).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Rosales; Rosaceae; Rosoideae; Potentilleae; Fragariinae;
OC   Fragaria.
OX   NCBI_TaxID=3747;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Fruit;
RA   Zuidmeer L., Salentijn E., Fernandez-Rivas M., Gonzalez Mancebo E.,
RA   Bolhaar S.T.H.P., Knulst A.C., Hoffmann-Sommergruber K., Asero R.,
RA   Matos C.I., Pelgrom K.T.B., Gilissen L.J.W.J., van Ree R.;
RT   "Cross-reactivity of a recombinant non-specific lipid transfer protein from
RT   strawberry.";
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC       At high concentrations, profilin prevents the polymerization of actin,
CC       whereas it enhances it at low concentrations. By binding to PIP2, it
CC       inhibits the formation of IP3 and DG (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Occurs in many kinds of cells as a complex with monomeric
CC       actin in a 1:1 ratio.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- ALLERGEN: Causes an allergic reaction in human.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR   EMBL; DR027057; -; NOT_ANNOTATED_CDS; mRNA.
DR   AlphaFoldDB; P0C0Y3; -.
DR   SMR; P0C0Y3; -.
DR   Allergome; 1172; Fra a 4.
DR   Allergome; 3287; Fra a 4.0101.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   CDD; cd00148; PROF; 1.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR036140; PFN_sf.
DR   InterPro; IPR027310; Profilin_CS.
DR   PANTHER; PTHR11604; PTHR11604; 1.
DR   Pfam; PF00235; Profilin; 1.
DR   PRINTS; PR00392; PROFILIN.
DR   PRINTS; PR01640; PROFILINPLNT.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
DR   PROSITE; PS00414; PROFILIN; 1.
PE   1: Evidence at protein level;
KW   Actin-binding; Allergen; Cytoplasm; Cytoskeleton.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..131
FT                   /note="Profilin"
FT                   /id="PRO_0000199631"
SQ   SEQUENCE   131 AA;  14067 MW;  FA5F579407D2B123 CRC64;
     MSWQTYVDDH LMCEIEGNHL SAAAIIGQDG SVWAQSATFP QLKPEEVTGI VRDFDEPGTL
     APTGLYLGGT KYMVIQGEPG AVIRGKKGPG GVTVKKTTLA LLIGIYDEPM TPGQCNMIVE
     RLGDYLVEQG L