ID   PROF_HEILC              Reviewed;         121 AA.
AC   A0A1Q9P359;
DT   12-AUG-2020, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2017, sequence version 1.
DT   25-MAY-2022, entry version 11.
DE   RecName: Full=Heimdall profilin {ECO:0000303|PubMed:30283132};
GN   ORFNames=HeimC2_04030;
OS   Heimdallarchaeota archaeon (strain LC_2).
OC   Archaea; Asgard group; Candidatus Heimdallarchaeota.
OX   NCBI_TaxID=1841597;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LC_2;
RX   PubMed=28077874; DOI=10.1038/nature21031;
RA   Zaremba-Niedzwiedzka K., Caceres E.F., Saw J.H., Backstrom D.,
RA   Juzokaite L., Vancaester E., Seitz K.W., Anantharaman K., Starnawski P.,
RA   Kjeldsen K.U., Scott M.B., Nunoura T., Banfield J.F., Schramm A.,
RA   Baker B.J., Spang A., Ettema T.J.G.;
RT   "Asgard archaea illuminate the origin of eukaryotic cellular complexity.";
RL   Nature 541:353-358(2017).
RN   [2]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=30283132; DOI=10.1038/s41586-018-0548-6;
RA   Akil C., Robinson R.C.;
RT   "Genomes of Asgard archaea encode profilins that regulate actin.";
RL   Nature 562:439-443(2018).
CC   -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC       At high concentrations inhibits spontaneous rabbit actin nucleation.
CC       This strongly suggests this archaea has a profilin-regulated actin
CC       system, and actin-type genes can be identified in this organism.
CC       {ECO:0000269|PubMed:30283132}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000305|PubMed:30283132}.
CC   -!- SIMILARITY: Belongs to the Asgard profilin family. {ECO:0000305}.
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DR   EMBL; MDVR01000008; OLS28802.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Q9P359; -.
DR   SMR; A0A1Q9P359; -.
DR   EnsemblBacteria; OLS28802; OLS28802; HeimC2_04030.
DR   Proteomes; UP000186209; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   InterPro; IPR036140; PFN_sf.
DR   SUPFAM; SSF55770; SSF55770; 1.
PE   3: Inferred from homology;
KW   Actin-binding; Cytoplasm; Cytoskeleton.
FT   CHAIN           1..121
FT                   /note="Heimdall profilin"
FT                   /id="PRO_0000450552"
SQ   SEQUENCE   121 AA;  12905 MW;  78715CAF97F064F9 CRC64;
     MSFNDKAAEA VASGDIGVGW LLSDQCEVFW NVGSWEGANP CEILTEWKKS AMTPITIAGL
     KFTIIGKTPE RLVSTNIGGQ GHIVGAKCTN YPGYLVCWCP ATVGPNIAYS VIQKLADLVK
     A