ID   PROF_HELAN              Reviewed;         133 AA.
AC   O81982;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Profilin;
DE   AltName: Full=Pollen allergen Hel a 2;
DE   AltName: Allergen=Hel a 2;
OS   Helianthus annuus (Common sunflower).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; campanulids; Asterales; Asteraceae; Asteroideae;
OC   Heliantheae alliance; Heliantheae; Helianthus.
OX   NCBI_TaxID=4232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND ALLERGEN.
RC   TISSUE=Pollen;
RX   PubMed=9798651; DOI=10.1016/s0161-5890(98)00036-4;
RA   Asturias J.A., Arilla M.C., Gomez-Bayon N., Aguirre M., Martinez A.,
RA   Palacios R., Martinez J.;
RT   "Cloning and immunological characterization of the allergen Hel a 2
RT   (profilin) from sunflower pollen.";
RL   Mol. Immunol. 35:469-478(1998).
CC   -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC       At high concentrations, profilin prevents the polymerization of actin,
CC       whereas it enhances it at low concentrations. By binding to PIP2, it
CC       inhibits the formation of IP3 and DG (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Occurs in many kinds of cells as a complex with monomeric
CC       actin in a 1:1 ratio.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- ALLERGEN: Causes an allergic reaction in human.
CC       {ECO:0000269|PubMed:9798651}.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR   EMBL; Y15210; CAA75506.1; -; mRNA.
DR   PIR; T31427; T31427.
DR   AlphaFoldDB; O81982; -.
DR   SMR; O81982; -.
DR   Allergome; 3307; Hel a 2.0101.
DR   Allergome; 377; Hel a 2.
DR   PRIDE; O81982; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   CDD; cd00148; PROF; 1.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR036140; PFN_sf.
DR   InterPro; IPR027310; Profilin_CS.
DR   PANTHER; PTHR11604; PTHR11604; 1.
DR   Pfam; PF00235; Profilin; 1.
DR   PRINTS; PR00392; PROFILIN.
DR   PRINTS; PR01640; PROFILINPLNT.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
DR   PROSITE; PS00414; PROFILIN; 1.
PE   1: Evidence at protein level;
KW   Actin-binding; Allergen; Cytoplasm; Cytoskeleton.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..133
FT                   /note="Profilin"
FT                   /id="PRO_0000199632"
SQ   SEQUENCE   133 AA;  14286 MW;  48D0E1D76350D73A CRC64;
     MSWQAYVDEH LMCDIEGTGQ HLTSAAILGL DGTVWAQSAK FPQFKPEEMK GIIKEFDEAG
     TLAPTGMFIA GAKYMVLQGE PGAVIRGKKG AGGICIKKTG QAMIMGIYDE PVAPGQCNMV
     VERLGDYLLE QGM