ID   PROF_LITCN              Reviewed;         131 AA.
AC   Q941H7;
DT   24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Profilin;
DE   AltName: Full=Minor allergen Lit c 1;
DE   AltName: Allergen=Lit c 1;
OS   Litchi chinensis (Lychee).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Sapindales; Sapindaceae; Litchi.
OX   NCBI_TaxID=151069;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Reindl J., Scheurer S., Wangorsch A., Haustein D., Vieths S.;
RT   "Characterization of the minor allergen lychee profilin (Litchi
RT   chinensis).";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC       At high concentrations, profilin prevents the polymerization of actin,
CC       whereas it enhances it at low concentrations. By binding to PIP2, it
CC       inhibits the formation of IP3 and DG (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Occurs in many kinds of cells as a complex with monomeric
CC       actin in a 1:1 ratio.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- ALLERGEN: Causes an allergic reaction in human.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR   EMBL; AY049013; AAL07320.1; -; mRNA.
DR   AlphaFoldDB; Q941H7; -.
DR   SMR; Q941H7; -.
DR   Allergome; 3353; Lit c 1.0101.
DR   Allergome; 449; Lit c 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   CDD; cd00148; PROF; 1.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR036140; PFN_sf.
DR   InterPro; IPR027310; Profilin_CS.
DR   PANTHER; PTHR11604; PTHR11604; 1.
DR   Pfam; PF00235; Profilin; 1.
DR   PRINTS; PR00392; PROFILIN.
DR   PRINTS; PR01640; PROFILINPLNT.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
DR   PROSITE; PS00414; PROFILIN; 1.
PE   1: Evidence at protein level;
KW   Actin-binding; Allergen; Cytoplasm; Cytoskeleton.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..131
FT                   /note="Profilin"
FT                   /id="PRO_0000199643"
SQ   SEQUENCE   131 AA;  14030 MW;  2723774C37677B81 CRC64;
     MSWQTYVDDH LMCETDGQHL TAAAIIGHDG SVWAQSANFP QFKPAEIAAI MKDFDEPGSL
     APTGLHLGGT KYMVIQGEPG AVIRGKKGPG GITVKKTTQA LIIGIYDEPM TPGQCNMVVE
     RLGDYLVDQG L