ID   PROF_MERAN              Reviewed;         133 AA.
AC   O49894;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Profilin;
DE   AltName: Full=Pollen allergen Mer a 1;
DE   AltName: Allergen=Mer a 1;
OS   Mercurialis annua (Annual mercury).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Malpighiales; Euphorbiaceae; Acalyphoideae; Acalypheae;
OC   Mercurialis.
OX   NCBI_TaxID=3986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND ALLERGEN.
RC   TISSUE=Pollen;
RX   PubMed=9525453; DOI=10.1016/s0091-6749(98)70249-0;
RA   Vallverdu A., Asturias J.A., Arilla M.C., Gomez-Bayon N., Martinez A.,
RA   Martinez J., Palacios R.;
RT   "Characterization of recombinant Mercurialis annua major allergen Mer a 1
RT   (profilin).";
RL   J. Allergy Clin. Immunol. 101:363-370(1998).
CC   -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC       At high concentrations, profilin prevents the polymerization of actin,
CC       whereas it enhances it at low concentrations. By binding to PIP2, it
CC       inhibits the formation of IP3 and DG (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Occurs in many kinds of cells as a complex with monomeric
CC       actin in a 1:1 ratio.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- ALLERGEN: Causes an allergic reaction in human.
CC       {ECO:0000269|PubMed:9525453}.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR   EMBL; Y13271; CAA73720.1; -; mRNA.
DR   AlphaFoldDB; O49894; -.
DR   SMR; O49894; -.
DR   Allergome; 3375; Mer a 1.0101.
DR   Allergome; 476; Mer a 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   CDD; cd00148; PROF; 1.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR036140; PFN_sf.
DR   InterPro; IPR027310; Profilin_CS.
DR   PANTHER; PTHR11604; PTHR11604; 1.
DR   Pfam; PF00235; Profilin; 1.
DR   PRINTS; PR00392; PROFILIN.
DR   PRINTS; PR01640; PROFILINPLNT.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
DR   PROSITE; PS00414; PROFILIN; 1.
PE   1: Evidence at protein level;
KW   Actin-binding; Allergen; Cytoplasm; Cytoskeleton.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..133
FT                   /note="Profilin"
FT                   /id="PRO_0000199654"
SQ   SEQUENCE   133 AA;  14300 MW;  06D8C6597217654F CRC64;
     MSWQTYVDDH LMCDIDGQGQ HLAAASIVGH DGSIWAQSAS FPQLKPEEIT GIMKDFDEPG
     HLAPTGLYIA GTKYMVIQGE SGAVIRGKKG SGGITIKKTG QALVFGIYEE PVTPGQCNMV
     VERLGDYLIE QGM