ID   PROF_MONPZ              Reviewed;         133 AA.
AC   Q8V4T7;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   02-JUN-2021, entry version 56.
DE   RecName: Full=Profilin;
GN   ORFNames=A42R;
OS   Monkeypox virus (strain Zaire-96-I-16) (MPX).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=619591;
OH   NCBI_TaxID=45479; Cynomys gunnisoni (Gunnison's prairie dog).
OH   NCBI_TaxID=99825; Cynomys leucurus (White-tailed prairie dog).
OH   NCBI_TaxID=45480; Cynomys ludovicianus (Black-tailed prairie dog).
OH   NCBI_TaxID=99826; Cynomys mexicanus (Mexican prairie dog).
OH   NCBI_TaxID=99827; Cynomys parvidens (Utah prairie dog).
OH   NCBI_TaxID=30650; Gliridae (dormice).
OH   NCBI_TaxID=226685; Heliosciurus ruwenzorii (Ruwenzori sun squirrel).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=10090; Mus musculus (Mouse).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Zaire-96-I-16;
RX   PubMed=11734207; DOI=10.1016/s0014-5793(01)03144-1;
RA   Shchelkunov S.N., Totmenin A.V., Babkin I.V., Safronov P.F.,
RA   Ryazankina O.I., Petrov N.A., Gutorov V.V., Uvarova E.A., Mikheev M.V.,
RA   Sisler J.R., Esposito J.J., Jahrling P.B., Moss B., Sandakhchiev L.S.;
RT   "Human monkeypox and smallpox viruses: genomic comparison.";
RL   FEBS Lett. 509:66-70(2001).
CC   -!- FUNCTION: More likely to influence phosphoinositide metabolism than
CC       actin assembly. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR   EMBL; AF380138; AAL40610.1; -; Genomic_DNA.
DR   RefSeq; NP_536579.1; NC_003310.1.
DR   PDB; 4QWO; X-ray; 1.52 A; A/B=1-133.
DR   PDBsum; 4QWO; -.
DR   SMR; Q8V4T7; -.
DR   GeneID; 928946; -.
DR   KEGG; vg:928946; -.
DR   Proteomes; UP000101269; Genome.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR036140; PFN_sf.
DR   InterPro; IPR027310; Profilin_CS.
DR   Pfam; PF00235; Profilin; 1.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
DR   PROSITE; PS00414; PROFILIN; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Actin-binding.
FT   CHAIN           1..133
FT                   /note="Profilin"
FT                   /id="PRO_0000199690"
FT   HELIX           1..12
FT                   /evidence="ECO:0007829|PDB:4QWO"
FT   STRAND          17..24
FT                   /evidence="ECO:0007829|PDB:4QWO"
FT   STRAND          26..28
FT                   /evidence="ECO:0007829|PDB:4QWO"
FT   STRAND          31..34
FT                   /evidence="ECO:0007829|PDB:4QWO"
FT   HELIX           40..42
FT                   /evidence="ECO:0007829|PDB:4QWO"
FT   HELIX           45..53
FT                   /evidence="ECO:0007829|PDB:4QWO"
FT   STRAND          65..73
FT                   /evidence="ECO:0007829|PDB:4QWO"
FT   TURN            77..79
FT                   /evidence="ECO:0007829|PDB:4QWO"
FT   STRAND          81..90
FT                   /evidence="ECO:0007829|PDB:4QWO"
FT   STRAND          93..98
FT                   /evidence="ECO:0007829|PDB:4QWO"
FT   STRAND          100..108
FT                   /evidence="ECO:0007829|PDB:4QWO"
FT   HELIX           114..129
FT                   /evidence="ECO:0007829|PDB:4QWO"
FT   TURN            130..132
FT                   /evidence="ECO:0007829|PDB:4QWO"
SQ   SEQUENCE   133 AA;  15003 MW;  2FF189D84198F2B9 CRC64;
     MAEWHKIIED ISKNNKFEDA AIVDYKTTKN VLAAIPNRTF AKINPGEVIP LITNHNILKP
     LIGQKFCIVY TNSLMDENTY AMELLTGYAP VSPIVIARTH TALIFLMGKP TTSRRDVYRT
     CRDHATRVRA TGN