ID   PROF_MUSAC              Reviewed;         131 AA.
AC   Q94JN3;
DT   24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Profilin;
DE   AltName: Full=Minor fruit allergen Mus xp 1;
DE   AltName: Allergen=Mus xp 1;
OS   Musa acuminata (Banana) (Musa cavendishii).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Zingiberales; Musaceae; Musa.
OX   NCBI_TaxID=4641;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND ALLERGEN.
RX   PubMed=12065910; DOI=10.1159/000059400;
RA   Reindl J., Rihs H.P., Scheurer S., Wangorsch A., Haustein D., Vieths S.;
RT   "IgE reactivity to profilin in pollen-sensitized subjects with adverse
RT   reactions to banana and pineapple.";
RL   Int. Arch. Allergy Immunol. 128:105-114(2002).
CC   -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC       At high concentrations, profilin prevents the polymerization of actin,
CC       whereas it enhances it at low concentrations. By binding to PIP2, it
CC       inhibits the formation of IP3 and DG (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Occurs in many kinds of cells as a complex with monomeric
CC       actin in a 1:1 ratio.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE. This is a
CC       food allergen. {ECO:0000269|PubMed:12065910}.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR   EMBL; AF377948; AAK54834.1; -; mRNA.
DR   AlphaFoldDB; Q94JN3; -.
DR   SMR; Q94JN3; -.
DR   Allergome; 7632; Mus a 1.
DR   Allergome; 7633; Mus a 1.0101.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   CDD; cd00148; PROF; 1.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR036140; PFN_sf.
DR   InterPro; IPR027310; Profilin_CS.
DR   PANTHER; PTHR11604; PTHR11604; 1.
DR   Pfam; PF00235; Profilin; 1.
DR   PRINTS; PR00392; PROFILIN.
DR   PRINTS; PR01640; PROFILINPLNT.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
DR   PROSITE; PS00414; PROFILIN; 1.
PE   1: Evidence at protein level;
KW   Actin-binding; Allergen; Cytoplasm; Cytoskeleton.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..131
FT                   /note="Profilin"
FT                   /id="PRO_0000199655"
SQ   SEQUENCE   131 AA;  14042 MW;  583A49241651F3E1 CRC64;
     MSWQAYVDDH LLCDIDGQCL TAAAIVGHDG SVWAQSDAFP QCKPEEIAAI MKDFDEPGSL
     APTGLYLGGT KYMVIQGEPG AVIRGKKGSG GVTIKKTNLA LIIGIYNEPM TPGQCNMVVE
     RLGDYLFDQG F