PROF_PLAF7
ID PROF_PLAF7 Reviewed; 171 AA.
AC Q8I2J4;
DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=Profilin {ECO:0000250|UniProtKB:P86294};
GN Name=Pfn {ECO:0000312|EMBL:CAD51999.1}; ORFNames=PFI1565w;
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [2] {ECO:0000312|EMBL:CAD51999.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
CC -!- FUNCTION: Essential for the invasive blood stages of the parasite.
CC Binds to proline rich sequences in various regulatory formin-like
CC proteins and also to membrane phospholipids. Binds to actin and affects
CC the structure of the cytoskeleton. Weakly sequesters actin monomers (By
CC similarity). {ECO:0000250|UniProtKB:P86294}.
CC -!- SUBUNIT: Binds actin. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000250|UniProtKB:P07274}.
CC -!- DOMAIN: The actin binding residues are poorly conserved between
CC Plasmodium and other organisms. The Plasmodium-specific profilin mini-
CC domain may have a role in binding to membrane phospholipids.
CC -!- SIMILARITY: Belongs to the profilin family. {ECO:0000255}.
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DR EMBL; AL844508; CAD51999.1; -; Genomic_DNA.
DR RefSeq; XP_001352188.1; XM_001352152.1.
DR AlphaFoldDB; Q8I2J4; -.
DR SMR; Q8I2J4; -.
DR DIP; DIP-46330N; -.
DR IntAct; Q8I2J4; 1.
DR STRING; 5833.PFI1565w; -.
DR PRIDE; Q8I2J4; -.
DR EnsemblProtists; CAD51999; CAD51999; PF3D7_0932200.
DR GeneID; 813593; -.
DR KEGG; pfa:PF3D7_0932200; -.
DR VEuPathDB; PlasmoDB:PF3D7_0932200; -.
DR HOGENOM; CLU_1630415_0_0_1; -.
DR InParanoid; Q8I2J4; -.
DR OMA; DITMCAR; -.
DR PhylomeDB; Q8I2J4; -.
DR Proteomes; UP000001450; Chromosome 9.
DR GO; GO:0015629; C:actin cytoskeleton; ISS:UniProtKB.
DR GO; GO:0005938; C:cell cortex; IBA:GO_Central.
DR GO; GO:0003785; F:actin monomer binding; ISS:UniProtKB.
DR GO; GO:0005543; F:phospholipid binding; ISS:UniProtKB.
DR GO; GO:0030036; P:actin cytoskeleton organization; ISS:UniProtKB.
DR GO; GO:0060327; P:cytoplasmic actin-based contraction involved in cell motility; ISS:UniProtKB.
DR GO; GO:0042989; P:sequestering of actin monomers; IBA:GO_Central.
DR InterPro; IPR005455; PFN.
DR InterPro; IPR036140; PFN_sf.
DR InterPro; IPR016814; Profilin_apicomplexa.
DR PANTHER; PTHR11604; PTHR11604; 1.
DR Pfam; PF00235; Profilin; 1.
DR PIRSF; PIRSF022993; Profilin_apicomplexa; 1.
DR SMART; SM00392; PROF; 1.
DR SUPFAM; SSF55770; SSF55770; 1.
PE 3: Inferred from homology;
KW Actin-binding; Cytoplasm; Cytoskeleton; Lipid-binding; Reference proteome.
FT CHAIN 1..171
FT /note="Profilin"
FT /id="PRO_0000377711"
FT REGION 5..10
FT /note="Pro-rich sequence-binding"
FT /evidence="ECO:0000250|UniProtKB:P86294"
FT REGION 100..112
FT /note="Actin-binding"
FT /evidence="ECO:0000250|UniProtKB:P86294, ECO:0000255"
FT REGION 152..156
FT /note="Actin-binding"
FT /evidence="ECO:0000250|UniProtKB:P86294, ECO:0000255"
FT MOTIF 48..54
FT /note="Plasmodium-specific profilin mini-domain"
FT /evidence="ECO:0000250|UniProtKB:P86294"
FT SITE 35
FT /note="Interaction with Pro-rich sequence"
FT /evidence="ECO:0000250"
FT SITE 89
FT /note="Interaction with actin"
FT /evidence="ECO:0000255"
SQ SEQUENCE 171 AA; 19017 MW; 1FFBC426787A132C CRC64;
MAEEYSWDSY LNDRLLATNQ VSGAGLASEE DGVVYACVAQ GEESDPNFDK WSLFYKEDYD
IEVEDENGTK TTKTINEGQT ILVVFNEGYA PDGVWLGGTK YQFINIERDL EFEGYNFDVA
TCAKLKGGLH LVKVPGGNIL VVLYDEEKEQ DRGNSKIAAL TFAKELAESS Q
