ID   PROF_PLALA              Reviewed;          42 AA.
AC   C0HJX6;
DT   15-MAR-2017, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2017, sequence version 1.
DT   25-MAY-2022, entry version 9.
DE   RecName: Full=Profilin {ECO:0000303|PubMed:28126622};
DE   AltName: Allergen=Pla l 2 {ECO:0000303|PubMed:28126622};
DE   Flags: Fragments;
OS   Plantago lanceolata (English plantain) (Ribwort plantain).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Lamiales; Plantaginaceae; Plantagineae; Plantago.
OX   NCBI_TaxID=39414 {ECO:0000303|PubMed:28126622};
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, ALLERGEN, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC   TISSUE=Pollen {ECO:0000303|PubMed:28126622};
RX   PubMed=28126622; DOI=10.1016/j.molimm.2017.01.017;
RA   Moya R., Rubio V., Beitia J.M., Carnes J., Lopez-Matas M.A.;
RT   "Purification and immunochemical characterization of Pla l 2, the profilin
RT   from Plantago lanceolata.";
RL   Mol. Immunol. 83:100-106(2017).
CC   -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC       At high concentrations, profilin prevents the polymerization of actin,
CC       whereas it enhances it at low concentrations.
CC       {ECO:0000250|UniProtKB:P35081}.
CC   -!- SUBUNIT: Occurs in many kinds of cells as a complex with monomeric
CC       actin in a 1:1 ratio. {ECO:0000250|UniProtKB:P35081}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:P35081}.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE.
CC       {ECO:0000269|PubMed:28126622}.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR   AlphaFoldDB; C0HJX6; -.
DR   Allergome; 11840; Pla l 2.
DR   Allergome; 11915; Pla l 2.0101.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Actin-binding; Allergen; Cytoplasm; Cytoskeleton;
KW   Direct protein sequencing.
FT   CHAIN           <1..>42
FT                   /note="Profilin"
FT                   /id="PRO_0000439276"
FT   UNSURE          2
FT                   /note="I or L"
FT                   /evidence="ECO:0000269|PubMed:28126622"
FT   UNSURE          3
FT                   /note="L or I"
FT                   /evidence="ECO:0000269|PubMed:28126622"
FT   UNSURE          14
FT                   /note="L or I"
FT                   /evidence="ECO:0000269|PubMed:28126622"
FT   UNSURE          16
FT                   /note="L or I"
FT                   /evidence="ECO:0000269|PubMed:28126622"
FT   UNSURE          23
FT                   /note="I or L"
FT                   /evidence="ECO:0000269|PubMed:28126622"
FT   UNSURE          31
FT                   /note="I or L"
FT                   /evidence="ECO:0000269|PubMed:28126622"
FT   UNSURE          33
FT                   /note="L or I"
FT                   /evidence="ECO:0000269|PubMed:28126622"
FT   UNSURE          37
FT                   /note="L or I"
FT                   /evidence="ECO:0000269|PubMed:28126622"
FT   UNSURE          38
FT                   /note="L or I"
FT                   /evidence="ECO:0000269|PubMed:28126622"
FT   UNSURE          42
FT                   /note="L or I"
FT                   /evidence="ECO:0000269|PubMed:28126622"
FT   NON_CONS        12..13
FT                   /evidence="ECO:0000303|PubMed:28126622"
FT   NON_CONS        21..22
FT                   /evidence="ECO:0000303|PubMed:28126622"
FT   NON_CONS        32..33
FT                   /evidence="ECO:0000303|PubMed:28126622"
FT   NON_TER         1
FT                   /evidence="ECO:0000303|PubMed:28126622"
FT   NON_TER         42
FT                   /evidence="ECO:0000303|PubMed:28126622"
SQ   SEQUENCE   42 AA;  4293 MW;  BD4AD4DA6DB09025 CRC64;
     AILGQDGSVW AQGLHLGGAK YVIAGEPGAV IRLGDYLLDQ GL