ID   PROF_PRUAV              Reviewed;         131 AA.
AC   Q9XF39;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Profilin;
DE   AltName: Full=Allergen Pru a 3;
DE   AltName: Allergen=Pru av 4;
OS   Prunus avium (Cherry) (Cerasus avium).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Amygdaleae; Prunus.
OX   NCBI_TaxID=42229;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11419723; DOI=10.1016/s0378-4347(01)00090-1;
RA   Scheurer S., Wangorsch A., Nerkamp J., Skov P.S., Ballmer-Weber B.,
RA   Wuthrich B., Haustein D., Vieths S.;
RT   "Cross-reactivity within the profilin panallergen family investigated by
RT   comparison of recombinant profilins from pear (Pyr c 4), cherry (Pru av 4)
RT   and celery (Api g 4) with birch pollen profilin Bet v 2.";
RL   J. Chromatogr. B 756:315-325(2001).
CC   -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC       At high concentrations, profilin prevents the polymerization of actin,
CC       whereas it enhances it at low concentrations. By binding to PIP2, it
CC       inhibits the formation of IP3 and DG (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Occurs in many kinds of cells as a complex with monomeric
CC       actin in a 1:1 ratio.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Food allergen.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR   EMBL; AF129425; AAD29411.1; -; mRNA.
DR   AlphaFoldDB; Q9XF39; -.
DR   SMR; Q9XF39; -.
DR   Allergome; 3450; Pru av 4.0101.
DR   Allergome; 600; Pru av 4.
DR   Proteomes; UP000515124; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   CDD; cd00148; PROF; 1.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR036140; PFN_sf.
DR   InterPro; IPR027310; Profilin_CS.
DR   PANTHER; PTHR11604; PTHR11604; 1.
DR   Pfam; PF00235; Profilin; 1.
DR   PRINTS; PR00392; PROFILIN.
DR   PRINTS; PR01640; PROFILINPLNT.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
DR   PROSITE; PS00414; PROFILIN; 1.
PE   1: Evidence at protein level;
KW   Actin-binding; Allergen; Cytoplasm; Cytoskeleton; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..131
FT                   /note="Profilin"
FT                   /id="PRO_0000199667"
SQ   SEQUENCE   131 AA;  13970 MW;  177212BD5D887B3E CRC64;
     MSWQAYVDDH LMCDIDGNRL TAAAILGQDG SVWSQSATFP AFKPEEIAAI LKDLDQPGTL
     APTGLFLGGT KYMVIQGEAG AVIRGKKGSG GITVKKTNQA LIIGIYDEPL TPGQCNMIVE
     RLGDYLIEQG L