ID   PROF_PRUDU              Reviewed;         131 AA.
AC   Q8GSL5;
DT   24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Profilin;
DE   AltName: Allergen=Pru du 4;
OS   Prunus dulcis (Almond) (Amygdalus dulcis).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Amygdaleae; Prunus.
OX   NCBI_TaxID=3755;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Wang F., Roux K.H., Teuber T.S., Sathe S.K.;
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC       At high concentrations, profilin prevents the polymerization of actin,
CC       whereas it enhances it at low concentrations. By binding to PIP2, it
CC       inhibits the formation of IP3 and DG (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Occurs in many kinds of cells as a complex with monomeric
CC       actin in a 1:1 ratio.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- ALLERGEN: Causes an allergic reaction in human.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR   EMBL; AY081850; AAL91662.1; -; mRNA.
DR   EMBL; AY081852; AAL91664.1; -; mRNA.
DR   AlphaFoldDB; Q8GSL5; -.
DR   SMR; Q8GSL5; -.
DR   Allergome; 1047; Pru du 4.
DR   Allergome; 3452; Pru du 4.0101.
DR   Allergome; 3453; Pru du 4.0102.
DR   PRIDE; Q8GSL5; -.
DR   EnsemblPlants; VVA24821; VVA24821; Prudul26B019649.
DR   Gramene; VVA24821; VVA24821; Prudul26B019649.
DR   OMA; NETMSWQ; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   CDD; cd00148; PROF; 1.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR036140; PFN_sf.
DR   InterPro; IPR027310; Profilin_CS.
DR   PANTHER; PTHR11604; PTHR11604; 1.
DR   Pfam; PF00235; Profilin; 1.
DR   PRINTS; PR00392; PROFILIN.
DR   PRINTS; PR01640; PROFILINPLNT.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
DR   PROSITE; PS00414; PROFILIN; 1.
PE   1: Evidence at protein level;
KW   Actin-binding; Allergen; Cytoplasm; Cytoskeleton.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..131
FT                   /note="Profilin"
FT                   /id="PRO_0000199668"
SQ   SEQUENCE   131 AA;  14061 MW;  01121FDD4680DA9C CRC64;
     MSWQQYVDDH LMCDIDGNRL TAAAILGQDG SVWSQSATFP AFKPEEIAAI LKDFDQPGTL
     APTGLFLGGT KYMVIQGEAG AVIRGKKGSG GITVKKTNQA LIIGIYDEPL TPGQCNMIVE
     RLGDYLIEQG L