ID   PROF_PRUPE              Reviewed;         131 AA.
AC   Q8GT39;
DT   19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Profilin;
DE   AltName: Allergen=Pru p 4.02;
OS   Prunus persica (Peach) (Amygdalus persica).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Amygdaleae; Prunus.
OX   NCBI_TaxID=3760;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Peelings;
RX   PubMed=12823124; DOI=10.1034/j.1398-9995.2003.00198.x;
RA   Rodriguez-Perez R., Fernandez-Rivas M., Gonzalez-Mancebo E.,
RA   Sanchez-Monge R., Diaz-Perales A., Salcedo G.;
RT   "Peach profilin: cloning, heterologous expression and cross-reactivity with
RT   Bet v 2.";
RL   Allergy 58:635-640(2003).
CC   -!- FUNCTION: Binds to actin and affects the structure of the cytoskeleton.
CC       At high concentrations, profilin prevents the polymerization of actin,
CC       whereas it enhances it at low concentrations. By binding to PIP2, it
CC       inhibits the formation of IP3 and DG (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Occurs in many kinds of cells as a complex with monomeric
CC       actin in a 1:1 ratio.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Food allergen.
CC   -!- SIMILARITY: Belongs to the profilin family. {ECO:0000305}.
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DR   EMBL; AJ491882; CAD37202.1; -; mRNA.
DR   AlphaFoldDB; Q8GT39; -.
DR   SMR; Q8GT39; -.
DR   STRING; 3760.EMJ03950; -.
DR   Allergome; 736; Pru p 4.
DR   Allergome; 738; Pru p 4.0201.
DR   eggNOG; KOG1755; Eukaryota.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   CDD; cd00148; PROF; 1.
DR   InterPro; IPR005455; PFN.
DR   InterPro; IPR036140; PFN_sf.
DR   InterPro; IPR027310; Profilin_CS.
DR   PANTHER; PTHR11604; PTHR11604; 1.
DR   Pfam; PF00235; Profilin; 1.
DR   PRINTS; PR00392; PROFILIN.
DR   PRINTS; PR01640; PROFILINPLNT.
DR   SMART; SM00392; PROF; 1.
DR   SUPFAM; SSF55770; SSF55770; 1.
DR   PROSITE; PS00414; PROFILIN; 1.
PE   1: Evidence at protein level;
KW   Actin-binding; Allergen; Cytoplasm; Cytoskeleton.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..131
FT                   /note="Profilin"
FT                   /id="PRO_0000199669"
SQ   SEQUENCE   131 AA;  13989 MW;  2487C99AF3E89756 CRC64;
     MSWQAYVDDH LMCEIEGNHL SAAAIIGHDG SVWAQSATFP QLKPEEVTGI LNDFNEPGSL
     APTGLYLGGT KYMVIQGEPG AVIRGKKGPG GVTVKKSTLA LLIGIYDEPM TPGQCNMIVE
     RLGDYLVEQG L